The conformational preferences and hydrogen-bonding motifs of several potential chemopreventive hydroxycinnamic derivatives were determined by inelastic neutron scattering spectroscopy. The aim is to understand their recognized beneficial activity and establish reliable structure–activity relationships for these types of dietary phytochemicals. A series of phenolic acids with different hydroxyl/methoxyl ring su...
Publicado em "Proceedings of the World Congress on Engineering 2014, vol. 1. ISBN 978-988-19252-7-5" ; The work presented here compares the performance of indoor positioning systems suitable for low power wireless sensor networks. Map matching, approximate positioning (weighted centroid) and exact positioning algorithms (least squares) were tested and compared in a small predefined indoor environment. We found...
The constant growth of the elderly population in the world creates new challenges and opportunities in health care systems. New technological solutions have to be found in order to meet the needs and demands of our aging society. The welfare and quality of life of the elderly population must be a priority. Continuous physical activity will play an important role, due to the increase of the retirement age. Howev...
Aqueous mixtures of 2,2,2-trifluoroethanol have received significant attention in the last years because their applications, such as working fluid in Rankine cycle thermal engines or as solvent in studies of protein stability (protein folding). From the fundamental point of view, fluoroalcohols have an amphyphile character, due to the simultaneous presence of a hydrophobic (and alkane-phobic) fluorinated surfac...
Estudo apresentado no Curso de Mestrado em Ciências Jurídico-Políticas da Faculdade de Direito da Universidade de Coimbra, na disciplina de Direito Administrativo, leccionada pelo Professor Doutor José Carlos Vieira de Andrade
Objective: The aim of this study was to adjust the zidovudine (AZT) release from solid tablets to an ideal profile, by developing matrices comprising swellable polymers with nonswellable ones. Methods: Directly compressed matrices comprised different ratios of hydroxypropylmethylcellulose K15M and K100M, ethylcellulose, and methacrylic acid (Eudragit® RS PO and Eudragit® RL PO) were prepared. Technological char...
A full conformational study of solid-state anhydrous adenine is reported, using vibrational spectroscopy techniques coupled to DFT calculations, for the isolated molecule and the solid. In both cases, the N9Hamino tautomer was found to be the predominant species, followed by the N7H-amino form. An excellent agreement was achieved between experiment and theory, both for wavenumbers and intensities (without the n...
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