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The in vitro mechanical properties of small diameter Poly(vinyl) alcohol hydrog...
Alexandre, Nuno; Nunes, Natacha; Rodrigues, Miguel; Maurício, Ana Colette; Luís, Ana Lúcia; Lopes, Ascensão; Santos, José DomingosIntroduction The production of artificial vascular grafts of small diameter is a fluorescing line of investigation. PVA is a biomaterial that has been used for several biomedical applications and nowadays as a vascular graft. However the mechanical properties were never characterized in vitro. It was our objective to produce small diameter PVA grafts and characterize their physical and mechanical properties for...
In vivo evaluation of the potencial of mesenchymal stem cells (MSCs) from whart...
Alexandre, Nuno; Lopes, Ascensão; Rodrigues, Miguel; Amorim, Irina; Pereira, Tiaho; Gärtner, Andrea; Maurício, Ana Colette; Santos, José DomingosIntroduction: The use of cellular systems for improving biointegration of medical devices is a current trend of tissue engineering. The biocompatibility is a key aspect that can influence the performance of medical devices, for that reason inflammatory and foreign body reaction must be evaluated in pre-clinical studies. MSCs can modify the interaction of biomaterials with tissues by several mechanisms through t...
Application of Vascular grafts od Polyvinyl alcohol hydrogel associated to mese...
Alexandre, Nuno; Lopes, Ascensão; Nunes, Natacha; Amorim, Irina; Maurício, Ana Colette; Santos, José Domingos; Luís, Ana LúciaApplication of vascular grafts of the polyvinyl alcohol hydrogel (PVA) associated with MSCs from Wharton jelly in an animal model (sheep). N Alexandre, MA Lopes, N Fernandes, M Rodrigues, I Amorim, AC Mauricio, AL Luís Introduction: There is a great demand for new artificial vascular grafts of small diameter (< 6 mm) due to the functional limitations of the currently used biomaterials (ePTFE and Dacron). Polyv...
Reparação de lesões do nervo periférico num modelo animal.
Luís, Ana Lúcia Emidia de JesusDoutoramento em Ciências Veterinárias ; Phd programmes in Veterinary Sciences
Application of artificial vascular polyvinyl alcohol hydrogel grafts in sheep -...
Alexandre, Nuno; Gärtner, Andrea; Amorim, Irina; Santos, José D.; Lopes, Maria Ascensão; Colette Maurício, Ana; Luís, Ana LúciaResearchers developed this project according with the tasks originally planned, so far focusing their research activities in the biocompatibility and functionality of vascular implants. The biocompatibility was studied by following the ISO standard 10993-6 for evaluation of medical devices through the evaluation and grading of inflammation caused by implants placed subcutaneously. The implants were placed in sh...
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