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Análise de tripletos e de repetições em estruturas primárias de DNA
Lousado, José Paulo FerreiraO desenvolvimento de equipamentos de descodificação massiva de genomas veio aumentar de uma forma brutal os dados disponíveis. No entanto, para desvendarmos informação relevante a partir da análise desses dados é necessário software cada vez mais específico, orientado para determinadas tarefas que auxiliem o investigador a obter conclusões o mais rápido possível. É nesse campo que a bioinformática surge, como a...
Audio folios management system for foreign language learning
Lousado, José; Oliveira, Isabel; Costa, Carlos M.; Roberto, Maria T.Teaching and learning using technology has, for some years, been the focus of various researchers. From vocational schools, through basic education to higher education, the use of teaching aids based on information technologies is now a common practice. Today, more than making large computing solutions to support the activities of e-learning, it is important to focus on software specific solutions whose cost of...
Análise de repetições em dados biológicos
Lousado, José; Oliveira, JoséThe decoding of the genomes has created new challenges on the scientific community linked to the area of computation and information technologies. Daily, new data is added to numerous databases with billions of records, coming from more advanced equipment, helping in decoding the genomes. Determine how important and relevant are these data in order to find value-added information and obviously turn them into kn...
GeneSplit - Uma Aplicação para o Estudo de Associações de Codões e de Aminoácid...
Lousado, José; Oliveira, José; Moura, Gabriela; Santos, ManuelA descodificação de genomas, em particular do genoma humano, constituiu um marco cientifico extremamente importante nas últimas décadas e veio abrir caminho a novas áreas de investigação como a genómica e a proteómica. Espera-se que os avanços de conhecimento introduzidos por estas áreas tragam novas perspectivas sobre a forma como são diagnosticadas e tratadas muitas das doenças actuais, nomeadamente as que tê...
Exploiting Codon-Triplets Association for Genome Primary Structure Analysis
Lousado, José; Oliveira, José; Moura, Gabriela; Santos, ManuelAbstract— The way evolution shapes the arrangement of synonymous codons within open reading frames (ORF) for fine tuning mRNA decoding efficiency is not yet understood. Since the ribosome has 3 tRNA binding sites, the context of triplets should be relevant to decoding fidelity and efficiency. We have developed a software application for large-scale analysis of codon-triplet associations to shed new light into t...
Codon-triplet context unveils unique features of the Candida albicans protein c...
Moura, Gabriela; Lousado, José; Pinheiro, Miguel; Carreto, Laura; Silva, Raquel; Oliveira, José; Santos, ManuelBACKGROUND: The evolutionary forces that determine the arrangement of synonymous codons within open reading frames and fine tune mRNA translation efficiency are not yet understood. In order to tackle this question we have carried out a large scale study of codon-triplet contexts in 11 fungal species to unravel associations or relationships between codons present at the ribosome A-, P- and E-sites during each de...
Large scale comparative genomics of codon context
Lousado, José; Moura, Gabriela; Pinheiro, Miguel; Oliveira, José; Santos, ManuelThe efficiency of protein synthesis is highly dependent on codon usage and codon context. Indeed, the choice of particular synonymous codons is constrained by neighbour codons (codon context) to optimize mRNA decoding speed and accuracy. This is related to spatial (steric) effects created by the need to accommodate 3 tRNAs in the ribosome A-, P- and E-sites. Since these tRNAs interact with each other, with thei...
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