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Antioxidant and vascular effects of gliclazide in type 2 diabetic rats fed high...
Sena, C. M.; Louro, T.; Matafome, P.; Nunes, E.; Monteiro, P.; Seiça, R.Diabetes mellitus is characterized by oxidative stress, which in turn determines endothelial dysfunction. Gliclazide is a sulphonylurea antidiabetic drug with antioxidant effects due to its azabicyclo-octyl ring. It has been reported to potentially protect the vasculature through improvements in plasma lipid levels and platelet function. We hypothesized that gliclazide has a beneficial effect on endothelial fun...
A role for atorvastatin and insulin combination in protecting from liver injury...
Matafome, P.; Nunes, E.; Louro, T.; Amaral, C.; Crisóstomo, J.; Rodrigues, L.; Moedas, A. R.; Monteiro, P.; Cipriano, A.; Seiça, R.Non-alcoholic fatty liver disease (NAFLD) is a major complication linked with the metabolic syndrome associated with dyslipidemia, inflammation, and oxidative stress. Impact of type 2 diabetes with hyperlipidemia in NAFLD has to be established, as well as the utility of commonly prescribed anti-diabetic and lipid-lowering agents in improving liver injury markers. Genetic type 2 diabetic Goto–Kakizaki rats were ...
Antioxidant and vascular effects of gliclazide in type 2 diabetic rats fed high...
Sena, CM; Louro, T; Matafome, P; Nunes, E; Monteiro, P; Seiça, RDiabetes mellitus is characterized by oxidative stress, which in turn determines endothelial dysfunction. Gliclazide is a sulphonylurea antidiabetic drug with antioxidant effects due to its azabicyclo-octyl ring. It has been reported to potentially protect the vasculature through improvements in plasma lipid levels and platelet function. We hypothesized that gliclazide has a beneficial effect on endothelial fun...
Effects of alpha-lipoic acid on endothelial function in aged diabetic and high-...
Sena, C. M.; Nunes, E.; Louro, T.; Proença, T.; Fernandes, R.; Boarder, M. R.; Seiça, R. M.Background and purpose: This study was conducted to investigate the effects of α-lipoic acid (α-LA) on endothelial function in diabetic and high-fat fed animal models and elucidate the potential mechanism underlying the benefits of α-LA. Experimental approach: Plasma metabolites reflecting glucose and lipid metabolism, endothelial function, urinary albumin excretion (UAE), plasma and aortic malondialdehyde (MDA...
A role for atorvastatin and insulin combination in protecting from liver injury...
Matafome, P; Nunes, E; Louro, T; Amaral, C; Crisóstomo, J; Rodrigues, L; Moedas, AR; Monteiro, P; Cipriano, MA; Seiça, RNon-alcoholic fatty liver disease (NAFLD) is a major complication linked with the metabolic syndrome associated with dyslipidemia, inflammation, and oxidative stress. Impact of type 2 diabetes with hyperlipidemia in NAFLD has to be established, as well as the utility of commonly prescribed anti-diabetic and lipid-lowering agents in improving liver injury markers. Genetic type 2 diabetic Goto-Kakizaki rats were ...
Soybean oil treatment impairs glucose-stimulated insulin secretion and changes ...
Nunes, E.; Peixoto, F.; Louro, T.; Sena, C.; Santos, M.; Matafome, P.; Moreira, P.; Seiça, R.Abstract We investigated the effect of sub-chronic soybean oil (SO) treatment on the insulin secretion and fatty acid composition of islets of Langerhans obtained from Goto-Kakizaki (GK), a model of type 2 diabetes, and normal Wistar rats. We observed that soybean-treated Wistar rats present insulin resistance and defective islet insulin secretion when compared with untreated Wistar rats. The decrease in insul...
Disfunção Endotelial na Diabetes Tipo 2: Efeito de Antioxidantes
Sena, CM; Nunes, E; Louro, T; Proença, T; Seiça, RMIndividuals with insulin resistance and diabetes mellitus have increased cardiovascular morbidity and mortality, caused in part by vascular complications. Endothelial dysfunction has been implicated in the pathogenesis of vascular diabetic disease. This abnormal function of the vasculature precedes cardiovascular disease and is associated with impaired endothelium-dependent vasorelaxation. The main etiology of ...
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