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Disseminação de isolados de Enterobacteriaceae produtores da carbapenemase KPC-3

Zoonotic potential of multidrug resistant Escherichia coli clonal groups in Por...

Objectives: Multidrug-resistant (MDR) plasmids together with clonal dissemination of resistant isolates are possibly the most successful combination of factors contributing to the spread of antibiotic resistance genes. Our aim was to identify clones associated with multidrug-resistance among human and dolphin isolates, in order to evaluate zoonotic potential and risk. Methods: Sixty two MDR human Escherichia co...

Carbapenemase-producing Enterobacteriaceae isolates collected in Portuguese hos...

Objectives: In Portugal, little is known on carbapenemase (CARB)-producing Enterobacteriaceae. The aim of this study was to identify the resistance mechanisms of Enterobacteriaceae isolates, identified at hospital laboratories as carbapenem (CA) non-susceptible. Methods: This study included 61 Enterobacteriaceae isolates (26 Klebsiella spp, 15 Escherichia coli, 9 Enterobacter spp, 6 Morganella morgannii, 4 Prot...

Phenotypic and molecular characterization of CMY-46 and CMY-50, two novel plasm...

Objectives: The identification of isolates containing AmpC β-lactamases is epidemiologically and clinically relevant. With this study we performed the phenotypic and molecular characterization of two new CMY-2-types, designated CMY-46 and CMY-50, encountered among a total of 1664 clinical non-duplicate isolates of various Enterobacteriaceae species. Methods: E. coli INSRA1169 and INSRA3413 were isolated from t...

Zoonotic potential of multidrug resistant Escherichia coli clonal groups in Por...

Multidrug-resistant (MDR) plasmids together with clonal dissemination of resistant isolates are possibly the most successful combination of factors contributing to the spread of antibiotic resistance genes. Our aim was to identify clones associated with multidrug-resistance among human and dolphin isolates, in order to evaluate zoonotic potential and risk. Sixty two MDR human Escherichia coli isolates were rand...

Polyclonal KPC-3-producing Enterobacteriaceae in Portugal

Water has been recognized as a reservoir for antibiotic resistance genes (ARG), where the presence of mobile genetic elements, including plasmids, favors their dissemination. It is noteworthy that nonpathogenic environmental organisms, where plasmids encoding multiple ARG are prevalent, can provide resistance to most classes of antimicrobials including beta-lactams, aminoglycosides, chloramphenicol, trimethopri...

Epidemiology and zoonotic potential of Escherichia coli CTX-M-15-producing isol...

Background: The recent spread of plasmid-located CTX-M-ESBL-encoding genes is a serious threat to the clinical efficacy of expanded-spectrum cephalosporins. This study proposes to identify the epidemiology of plasmid-mediated CTX-M-encoding genes between an Escherichia coli strain isolated from a dolphin and several E. coli strains of human origin and, explain the responsible mechanism and reservoirs of current...