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Regulation of mitochondrial biogenesis by nitric oxide during neural stem cell ...

The presence of neural stem cells (NSC) in the mammalian brain allows the formation of new neurons (neurogenesis) during adult life. Following injury, neurogenesis may increase in an attempt to repair the lesioned area. However, the resulting neuroinflammation, characterized by activation of microglia, can be detrimental to neurogenesis. Nitric oxide (NO•) is released by microglia in these conditions, and our g...