Encontrados 52 documentos, a visualizar página 1 de 6
Evaluating web site structure based on navigation profiles and site topology
Simões, Alberto; Lourenço, Anália; Almeida, J. J.This work aims at pointing out the benefits of a topology-oriented wide scope, but differentiated, profile analysis. The goal was to conciliate advanced common website usage profiling techniques with the analysis of the website's topology information, outputting valuable knowledge in an intuitive and comprehensible way. Server load balancing, crawler activity evaluation and Web site restructuring are the primar...
Evaluation of linear classifiers on articles containing pharmacokinetic evidenc...
Kolchinsky, A.; Lourenço, Anália; Li, L.; Rocha, Luís M.Background. Drug-drug interaction (DDI) is a major cause of morbidity and mortality. DDI research includes the study of different aspects of drug interactions, from in vitro pharmacology, which deals with drug interaction mechanisms, to pharmaco-epidemiology, which investigates the effects of DDI on drug efficacy and adverse drug reactions. Biomedical literature mining can aid both kinds of approaches by extrac...
A new approach to bacterial colony morphotyping by matrix-assisted laser desorp...
Sousa, Ana Margarida; Nunes-Miranda, J. D.; Reboiro-Jato, M.; Fdez-Riverola, Florentino; Lourenço, Anália; Pereira, M. O.; Capelo, José LuisMatrix assisted laser desorption ionization time of flight mass spectrometry has been explored as a tool to bacterial colony morphotyping.To this end,four colony morphotypes of Pseudomonas aeruginosa and four of Staphylococcus aureus were analysed using intact bacteria.Results suggest that mass spectrometry of intact bacteria could,in some extent,be used to complement the classical morphological classification ...
ProFuelDB : an open-access database of physiological properties of biofuel-prod...
Lourenço, C. P.; Pereira, M. A.; Lourenço, Anália; Sousa, D. Z.Anaerobic microorganisms are attractive for the synthesis of fuels and chemicals, but information on the physiology of culturable anaerobes is dispersed in scientific literature. Herewith we present the ProFuelDB, a web-based publicly available database prototype compiling information on the physiology of anaerobic prokaryotes with relevance for biofuels production. It is foreseen that this prototype will evolv...
A systematic approach to the interrogation and sharing of standardised biofilm ...
Lourenço, Anália; Ferreira, Andreia; Pereira, M. O.; Azevedo, N. F.Publicado em "6th International Conference on Practical Applications of Computational Biology & Bioinformatics", ISBN 978-3-642-28838-8 ; The study of microorganism consortia, also known as biofilms, is associated to a number of applications in biotechnology, ecotechnology and clinical domains. A public repository on existing biofilm studies would aid in the design of new studies as well as promote collaborati...
MorphoCol : a powerful tool for the clinical profiling of pathogenic bacteria
Sousa, Ana Margarida; Lourenço, Anália; Pereira, Maria OlíviaPathogenicity, virulence and resistance of infection-causing bacteria are noteworthy problems in clinical settings, even after disinfection practices and antibiotic courses. Although it is common knowledge that these traits are associated to phenotypic and genetic variations, recent studies indicate that colony morphology variations are a sign of increased bacterial resistance to antimicrobial agents (i.e. anti...
Text mining for the biocuration workflow
Hirschman, L.; Burns, G. A. P. C.; Krallinger, M.; Arighi, C.; Cohen, K. B.; Valencia, A.; Hu, C. H.; Chatr-Aryamontri, A.; Dowell, K. G.; Huala, E.Molecular biology has become heavily dependent on biological knowledge encoded in expert curated biological databases. As the volume of biological literature increases, biocurators need help in keeping up with the literature; (semi-) automated aids for biocuration would seem to be an ideal application for natural language processing and text mining. However, to date, there have been few documented successes for...
BiofOmics : a web platform for the systematic and standardized collection of hi...
Lourenço, Anália; Ferreira, Andreia; Veiga, Nuno; Machado, Idalina; Pereira, M. O.; Azevedo, N. F.Background: Consortia of microorganisms, commonly known as biofilms, are attracting much attention from the scientific community due to their impact in human activity. As biofilm research grows to be a data-intensive discipline, the need for suitable bioinformatics approaches becomes compelling to manage and validate individual experiments, and also execute inter-laboratory large-scale comparisons. However, bio...
Computational approaches to standard-compliant biofilm data for reliable analys...
Sousa, Ana Margarida; Ferreira, Andreia; Azevedo, N. F.; Pereira, M. O.; Lourenço, AnáliaThe study of microorganism consortia, also known as biofilms, is associated to a number of applications in biotechnology, ecotechnology and clinical domains. Nowadays, biofilm studies are heterogeneous and data-intensive, encompassing different levels of analysis. Computational modelling of biofilm studies has become thus a requirement to make sense of these vast and ever-expanding biofilm data volumes. The rat...
A linear classifier based on entity recognition tools and a statistical approac...
Lourenço, Anália; Conover, M.; Wong, A.; Nematzadeh, A.; Pan, F.; Shatkay, Hagit; Rocha, Luís M.Background We participated, as Team 81, in the Article Classification and the Interaction Method subtasks (ACT and IMT, respectively) of the Protein-Protein Interaction task of the BioCreative III Challenge. For the ACT, we pursued an extensive testing of available Named Entity Recognition and dictionary tools, and used the most promising ones to extend our Variable Trigonometric Threshold linear classifier. O...
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