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Pneumonia necrotizante – um olhar sobre a imagem
Aguiar, Cláudia; Oliveira, Juliana; Correia, Joana; Ramos, Sandra; Pereira, José Silva; Silva, Conceição; Dinis, Maria JoséCriança do sexo feminino com quatro anos e antecedentes irrelevantes, foi levada ao serviço de urgência por apresentar há quatro dias febre elevada, tosse, gemido e recusa alimentar. Apresentava prostração, ar séptico, tiragem inter e subcostal, diminuição do murmúrio vesicular na metade inferior direita, sem hipoxemia. A telerradiografia pulmonar mostrou hipotransparência nos 2/3 superiores do hemitórax Direit...
Gellan gum-based hydrogel bilayered scaffolds for osteochondral tissue engineering
Pereira, D. R.; Canadas, Raphael F.; Correia, Joana Silva; Marques, A. P.; Reis, R. L.; Oliveira, Joaquim M.It has been shown that hydrogel bilayered scaffolds combining cartilage- and bone-like layers are most advantageous for treating osteochondral defects. In this study, it is proposed the use of low acyl gellan gum (LAGG) for developing bilayered hydrogel scaffolds for osteochondral tissue engineering. The cartilage-like layer of the GG-based bilayered hydrogel scaffolds is composed of LAGG (2 wt%). By adding a 2...
A glimpse from the past: osteoporosis and osteoporotic fractures in a portugues...
Curate, Francisco; Albuquerque, Anabela; Correia, Joana; Ferreira, Izilda; Pedroso de Lima, João; Cunha, EugéniaThe diachronic variation of etiological factors, like longevity or diet, affected the prevalence of osteoporosis and the so-called osteoporotic fractures in the past. As such, it is important to understand the epidemiology of this disease in historical populations; with behaviors and customs that were unalike the modern westernized lifestyle. Objectives: The main objective of this study is to characterize the e...
Toxicity of eucalypt and pine leaf extracts in fish and frogs
Correia, Joana Raquel de Aguiar MedeirosA desmatação de florestas naturais, aliada à crescente extensão de florestas plantadas, de monoculturas, como o eucalipto e o pinheiro, leva à perda de biodiversidade e tem outras consequências que são particularmente nefastas em ribeiros intermitentes, prejudicando os organismos aquáticos, como peixes e anfíbios. O presente estudo teve como principais objetivos: (i) avaliar as características físico-químicas d...
Bioactive macro/micro porous silk fibroin/Nano-sized calcium phosphate scaffold...
Yan, Leping; Correia, Joana Silva; Correia, C.; Caridade, S. G.; Fernandes, E. M.; Sousa, R. A.; Mano, J. F.; Oliveira, Joaquim M.; Oliveira, A. L.Aim: The development of novel silk/nano-sized calcium phosphate (silk/nano-CaP) scaffolds with highly dispersed CaP nanoparticles in the silk fibroin (SF) matrix for bone tissue engineering. Materials & methods: Nano-CaP was incorporated in a concentrated aqueous SF solution (16 wt.%) by using an in situ synthesis method. The silk/nano-CaP scaffolds were then prepared through a combination of salt-leaching/ lyo...
Development of nanofiber-reinforced hydrogel scaffolds for nucleus pulposus reg...
Thorvaldsson, A.; Correia, Joana Silva; Oliveira, Joaquim M.; Reis, R. L.; Gatenholm, P.; Walkenström, P.In this work a new method is presented to efficiently produce hydrogel scaffolds reinforced with nanofibers to show enhanced mechanical properties and improved structural integrity. The method is based on a combination of air brush spraying of a hydrogel and electrospinning of nanofibers. With air brush spraying the controllability is enhanced and the potential for scale-up increased. The developed method was u...
Hydrogels in acellular and cellular strategies for intervertebral disc regenera...
Pereira, D. R.; Correia, Joana Silva; Oliveira, Joaquim M.; Reis, R. L.Low back pain is an extremely common illness syndrome that causes patient suffering and disability and requires urgent solutions to improve the quality of life of these patients. Treatment options aimed to regenerate the intervertebral disc (IVD) are still under development. The cellular complexity of IVD, and consequently its fine regulatory system, makes it a challenge to the scientific community. Biomaterial...
Migration of “bioabsorbable” screws in ACL repair. How much do we know? a syste...
Pereira, H.; Correlo, V. M.; Correia, Joana Silva; Oliveira, Joaquim M.; Reis, R. L.; Mendes, João EspregueiraPurpose Although bioabsorbable screws promise to degrade within months up to several years after implantation, often this does not happen. In fact, other problems such as screw breakage, tunnel enlargement, allergic or foreign body reactions, cyst or abscess formation, and delayedmigration of ‘‘biodegradable’’ screws have been reported. This study aims to provide relevant basic science knowledge and recent insi...
Silk-Fibroin/Methacrylated Gellan Gum Hydrogel as an novel scaffold for applica...
Pereira, H.; Correia, Joana Silva; Yan, Leping; Caridade, S. G.; Frias, A. M.; Oliveira, A. L.; Mano, J. F.; Oliveira, Joaquim M.Introduction: Knee meniscus injury is highly prevalent and there is a demand for new cost-effective treatment solutions. Tissue engineering (TE) and regenerative medicine strategies using acellular scaffolds are being used in clinical application for total or partial meniscus replacement [1]. Although this strategy has been considered as a safe and promising approach, progressive volume reduction of the implant...
Biological characterization of rabbit nucleus pulposus cells on a biphasic scaf...
van Uden, Sebastião; Correia, Joana Silva; Correlo, V. M.; Oliveira, Joaquim M.; Reis, R. L.Intervertebral disc (IVD) degeneration (IDD) is nowadays considered as the main physiological cause for low back pain (LBP). LBP is known to affect people of any age, having a world socioeconomic burden of 70 billion euros per year[1]. Current LBP treatments only treat the symptoms without solving the problem. So, finding new ways of treating IDD is finding new ways of reducing socioeconomic impact created by L...
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