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Lamotrigine analysis in blood and brain by high-performance liquid chromatography
Castel-Branco, M. M.; Almeida, A. M.; Falcão, A. C.; Macedo, T. A.; Caramona, M. M.; Lopez, F. G.A reversed-phase high-performance liquid chromatography assay was developed and validated to determine plasma and brain lamotrigine concentrations allowing pharmacokinetic-pharmacodynamic studies of this new antiepileptic drug in patients and laboratory animals. Lamotrigine and its internal standard were extracted, under alkaline conditions, from plasma and brain homogenate, into ethyl acetate; brain proteins w...
Lamotrigine analysis in blood and brain by high-performance liquid chromatography
Castel-Branco, M. M.; Almeida, A. M.; Falcão, Amílcar; Macedo, T. A.; Caramona, M. M.; Lopez, F. G.A reversed-phase high-performance liquid chromatography assay was developed and validated to determine plasma and brain lamotrigine concentrations allowing pharmacokinetic-pharmacodynamic studies of this new antiepileptic drug in patients and laboratory animals. Lamotrigine and its internal standard were extracted, under alkaline conditions, from plasma and brain homogenate, into ethyl acetate; brain proteins w...
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