Encontrados 10 documentos, a visualizar página 1 de 1
Anti-inflammatory activity of Cymbopogon citratus leaves infusion via proteasom...
Francisco, Vera; Costa, Gustavo; Figueirinha, Artur; Marques, Carla; Pereira, Paulo; Neves, Bruno Miguel; Lopes, Maria Celeste; García-Rodríguez, CarmenEthnopharmacological relevance Cymbopogon citratus (DC.) Stapf leaves infusion is used in traditional medicine for the treatment of inflammatory conditions, however little is known about their bioactive compounds. Aim of the study Investigate the compounds responsible for anti-inflammatory potential of Cymbopogon citratus (Cy) on cytokines production induced by lipopolysaccharide (LPS) in human and mouse macro...
Pathogen Strategies to Evade Innate Immune Response: A Signaling Point of View
Neves, Bruno Miguel; Lopes, Maria Celeste; Cruz, Maria TeresaAn effective host defense against pathogens requires appropriate recognition of the invading microorganism by immune cells, conducing to an inflammatory process that involves recruitment of leukocytes to the site of infection, activation of antimicrobial effector mechanisms and induction of an adaptive immune response that ultimately will promote the clearance of infection. All these events require the coordina...
Espaço, media e experiência. Na era do espaço virtual e do tempo real
Cruz, Maria TeresaAs transformações da experiência, que a modernidade pensava fundamentalmente no tempo (como história, revolução e progresso), pensa-as a contemporaneidade numa relação intrínseca com o espaço. Na sociedade e na cultura em que as tecnologias da informação se tornam numa mediação generalizada da experiência, crescem de facto as alusões a uma relação fundamental com o espaço (mundialização, globalização, espaço vi...
Cymbopogon citratus as source of new and safe anti-inflammatory drugs: Bio-guid...
Francisco, Vera; Figueirinha, Artur; Neves, Bruno Miguel; García-Rodríguez, Carmen; Lopes, Maria Celeste; Cruz, Maria Teresa; Batista, Maria TeresaEthnopharmacological relevance Aqueous extracts of Cymbopogon citratus (Cy) leaves are used in traditional medicine for the treatment of inflammatory conditions, however, little is known about their mechanism of action. Aim of the study The aim of this study is to explore the anti-inflammatory properties of Cymbopogon citratus leaves and their polyphenol-rich fractions (PFs), as well its mechanism of action i...
Essential oils from Distichoselinum tenuifolium: Chemical composition, cytotoxi...
Tavares, Ana Cristina; Gonçalves, Maria José; Cruz, Maria Teresa; Cavaleiro, Carlos; Lopes, Maria Celeste; Canhoto, Jorge; Ribeiro Salgueiro, LigiaEthnopharmacological relevance: Several aromatic plants and their essential oils are known to possess antimicrobial and anti-inflammatory properties. Distichoselinum tenuifolium (Lag.) Garcia Martin & Silvestre, an Iberian endemism, is traditionally used in the treatment of contact dermatitis and skin infections. However, the cellular mechanisms through which this plant exerts their beneficial effects are not k...
Essential oil of Daucus carota subsp. halophilus: Composition, antifungal activ...
Tavares, Ana Cristina; Gonçalves, Maria José; Cavaleiro, Carlos; Cruz, Maria Teresa; Lopes, Maria Celeste; Canhoto, Jorge; Ribeiro Salgueiro, LigiaEthnopharmacological relevance: Essential oils are known to possess antimicrobial activity against a wide spectrum of bacteria and fungi. Daucus carota L. is used since olden times in traditional medicine, due to recognized therapeutic properties, namely the antimicrobial activity of their essential oils. Aim of the study: In the present study the composition and the antifungal activity of the oils of Daucus ca...
Differential modulation of CXCR4 and CD40 protein levels by skin sensitizers an...
Neves, Bruno Miguel; Cruz, Maria Teresa; Francisco, Vera; Gonçalo, Margarida; Figueiredo, Américo; Duarte, Carlos B.; Lopes, Maria CelesteThe development of non-animal methods for skin sensitization testing is an urgent challenge. Some of the most promising in vitro approaches are based on the analysis of phenotypical and functional modifications induced by sensitizers in dendritic cell models. In this work, we evaluated, for the first time, a fetal skin-derived dendritic cell line (FSDC) as a model to discriminate between sensitizers and irritan...
The Sensitizers Nickel Sulfate and 2,4-dinitrofluorobenzene Increase CD40 and I...
Vital, Ana Luísa; Gonçalo, Margarida; Cruz, Maria Teresa; Figueiredo, Américo; Duarte, Carlos B.; Lopes, Maria CelesteDendritic cells (DCs) are antigen-presenting cells (APCs) capable of capturing haptens and to process and present them to T lymphocytes. In order to sensitize T cells for contact hypersensitivity (CHS), skin DCs suffer a maturation process with modifications on their surface molecules. The aim of this work was to evaluate changes induced by two contact sensitizers, 2,4-dinitrofluorobenzene (DNFB) and nickel sul...
The Sensitizer 2,4-Dinitrofluorobenzene Activates Caspase-3 and Induces Cell De...
Cruz, Maria Teresa; Duarte, Carlos B.; Gonçalo, Margarida; Figueiredo, Américo; Carvalho, Arsélio P.; Lopes, Maria CelesteIn this work, a dendritic cell line derived from mouse skin (FSDC) was used, as an in vitro experimental model, to evaluate the cytotoxic effect of two chemical sensitizers, a strong sensitizer (2,4-dinitrofluorobenzene, DNFB) and a weak sensitizer (2,4- dichloronitrobenzene, DCNB). The results indicated that DNFB reduces the cellular metabolism of FSDC, as evaluated by the reduction of the tetrazolium salt, 3-...
Designação dos limites : o trabalho do nome na constituição da obra de arte mod...
Cruz, Maria Teresa Pimentel PeitoDissertação de Mestrado em Comunicação Social ; Há mais de um século atrás, há mais de 150 anos, um primeiro vaticíno de morte recaiu sobre a arte e, desde então, a reflexão sobre ela não pode mais pensar sem essa sombra, confirmando-a, aceitando-a, ou renegando-a. Esse vaticínio foi o de Hegel, nas Aesthetischen Lehren, (redigidas entre 1815 e 1829), curiosamente, no momento culminante, e pelo sistema mais ac...
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