Encontrados 15 documentos, a visualizar página 1 de 2
Contribution of freely available databases for the accurate classification of e...
João, Inês; Cristóvão, Paula; Jordao, LuisaOBJECTIVES: Nontuberculous mycobacteria (NTM) are a heterogeneous group of microorganisms. Their clinical relevance and treatment differs significantly upon NTM species, which makes identification at this level crucial. Additionally, inaccurate diagnosis can lead to therapeutic approaches consistent with Mycobacterium tuberculosis infection which are usefulness.In the present study different molecular methods w...
Exploitation of a link between antibacterial agent-resistance and biofilm-forma...
João, Inês; Reis, Lúcia; Carvalho, Patrícia; Duarte, Aida; Jordão, LuisaObjectives: In recent years nosocomial infections have gained growing importance. Among their etiological agents are “classical” pathogens such as S.aureus and also emergent pathogens, previously neglected, such as nontuberculous mycobacteria (MTM). The ability to resist to antibacterial agents, such as antibiotics and disinfectants, is shared by all of them. Here we aim to establish a link between bacterial vi...
Polymorphism in gidB gene as a genetic marker for the mycobacterium tuberculosi...
Perdigão, João; Macedo, Rita; Machado, Diana; Silva, Carla; Jordão, Luisa; Couto, Isabel; Viveiros, Miguel; Portugal, IsabelDevelopment of streptomycin-resistance in Mycobacterium tuberculosis is usually associated with mutations in rpsL and rrs genes, although up to 50% of clinical streptomycin-resistant isolates may present no mutation in either of these genes. The situation in Lisbon Health Region is similar, although mutations in rrs gene are only rarely detected. In the present report we investigate the role of gidB gene mutati...
Novel Mutations in pncA, Associated With Catalytic Centre, Might Be Related Wit...
Silva, Carla; Perdigao, João; Jordao, Luísa; Portugal, IsabelTuberculosis (TB) remains a serious health problem worldwide, and the greatest threat to TB control is the emergence of multidrug (MDR) Mycobacterium tuberculosis (Mtb) strains. Pyrazinamide (PZA) is an important first-line anti-TB drug. The emergence of isolates resistant to PZA, associated with MDR resistance, difficult TB treatment options. In order to evaluate mutations that might be responsible for PZA res...
Genomic diversity of drug-resistant mycobacterium tuberculosis isolates in Lisb...
Perdigão, João; Silva, Hugo; Machado, Diana; Macedo, Rita; Maltez, Fernando; Silva, Carla; Jordão, Luisa; Couto, Isabel; Mallard, Kim; Coll, FrancescMultidrug- (MDR) and extensively drug resistant (XDR) tuberculosis (TB) present a challenge to disease control and elimination goals. Lisbon, Portugal, has a high TB incidence rate and, unusual and successful XDR-TB strains that are found in circulation for almost two decades. In the present study, 56 Mycobacterium tuberculosis isolates, mostly recovered in Lisbon, were genotyped by 24-loci Mycobacterial Inters...
Exploring a link between pathogens structure's and resistance to
João, Inês; Reis, Lúcia; Carvalho, Patrícia; Duarte, Aida; Jordão, LuisaIn recent years healthcare-associated infections (HAIs) infections have gained growing importance. Among their etiological agents are classical (e.g. K. pneumoniae, S. aureus) and emergent pathogens, previously neglected, such as nontuberculous mycobacteria (NTM). The ability to resist to antibacterial agents, such as antibiotics and disinfectants, is shared by all of them. Here we aim to establish a link betwe...
Bacterial biofilms, antibiotic resistance and healthcare-associated infections:...
Bandeira, Maria; Carvalho, Patrícia; Duarte, Aida; Jordão, LuisaIn 2012, were estimated 6.7 million cases of healthcare-associated infections (HAI) either in long-term care facilities or acute-care hospitals from which result 37,000 deaths configuring a serious public health problem [1]. The etiological agents are diverse and often resistant to antimicrobial agents. One of the mechanisms responsible for the emergence of drug resistance is biofilm assembly. Biofilms are defi...
Correlation between streptomycin intermediate-level resistance and gidB mutatio...
Perdigao, joão; Macedo, Rita; Machado, Diana; Silva, Carla; Jordao, Luisa; Couto, Isabel; Viveiros, Miguel; Portugal, IsabelDevelopment of streptomycin-resistance in Mycobacterium tuberculosis is usually associated with mutations in rpsL and rrs genes, although up to 50% of clinical streptomycin-resistant isolates may present no mutation in either of these genes. The situation in Lisbon Health Region is similar, although mutations in rrs geneare only rarely detected. In the present report we investigate the role of gidB gene mutatio...
Exploring a link between mycobacteria structure and virulence
Silva, Carla; Perdigao, Joao; Alverca, Elsa; Matos, António Pedro Alves; Carvalho, Patrícia A; Portugal, Isabel; Jordao, LuisaTuberculosis (TB) is a major health problem. The emergence of multidrug resistant (MDR)Mycobacterium tuberculosis (Mtb) isolates confounds treatment strategies. In Portugal, cases of MDR-TB are reported annually with increased incidence noted in Lisbon. The majority of these MDR-TB cases are due to closely-related mycobacteria known collectively as Lisboa family and Q1 cluster. The genetic determinants linked t...
Morphologic characterization of Mycobacterium tuberculosis circulating strains ...
Silva, Carla; Alverca, Elsa; Matos, António Pedro; Carvalho, Patricia A; Portugal, Isabel; Jordao, LuisaAbstrat publicado em: http://metallica.civil.ist.utl.pt/~patricia/SPMicros2012/book.pdf ; Tuberculosis (TB) is one of the major causes of mortality and morbidity worldwide accounting for 3.1 million deaths per year. This disease, caused by M. tuberculosis (Mtb) made a deadly, during the 1990’s, triggered mainly by the emergence of acquired immunodeficiency syndrome (AIDS). More recently, the emergence of multi...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||