Encontrados 18 documentos, a visualizar página 1 de 2
Mineralogical composition of ceramics from Garvao iron age votive deposit (Port...
Rosado, L.; Candeias, A.; Moita, P.; Tavares, D.; Mayet, D.; Lopes, M.C.; Alfenim, R.; Mirão, J.In 1982, a votive deposit was discovered in Garvão (SW Portugal) revealing an important Iron Age II holy site. The pottery recovered shows that during Iron Age this archeological site was a merging geostrategic point of the Iberian societies with strong influences of the Mediterranean world and the Iberia celtic influences. Raw materials used by these communities provide essential information to understand spec...
Expression and function of the insulin receptor in normal and osteoarthritic hu...
Rosa, S. C.; Rufino, A. T.; Judas, F.; Tenreiro, C.; Lopes, M. C.; Mendes, A. F.Objective Chondrocytes respond to insulin, but the presence and role of the specific high affinity insulin receptor (InsR) has never been demonstrated. This study determined whether human chondrocytes express the InsR and compared its abundance and function in normal and osteoarthritis (OA) human chondrocytes. Design Cartilage sections were immunostained for detection of the InsR. Non-proliferating chondrocyt...
Efeitos da radiação em culturas celulares normais de amniócitos humanos e macró...
Santos, A. C.; Lopes, M. C.; Pinto, M.; Carreira, I.; Aleixo, I.; Rolo, I.; Neves, L.; Costa, R.; Cordeiro, R.; Ferreira, C.; Almeida, G.; Tavares, H.Resumo do poster apresentado ao XII Congresso Nacional de Medicina Nuclear, 12-14 Novembro 2009, Mealhada
Avaliação dos efeitos adversos de entomopatógenos sobre peixes e camundongos.
OLIVEIRA FILHO, E. C. de; RAMOS, F. R.; MUNIZ, D. H. de F.; LOPES, M. C.; OLIVEIRA, R. da S.; ALVES, R. T.; GRISOLIA, C. K.; PONTES, R. G. M. S. deNeste estudo, quatro cepas de Bacillus foram testadas para avaliar seus efeitos adversos sobre peixes e camundongos. Concentrações foram testadas de acordo com protocolos internacionais na faixa de 106 e 108 esporos por mililitro para peixes e dose de 108 esporos por animal para camundongos. Não houve letalidade em nenhuma das espécies testadas. No estudo de necrose-apoptose com eritrócitos periféricos de O. ni...
Nitric oxide synthase isoforms and NF-jB activity in normal and osteoarthritic ...
Rosa, Susana C.; Judas, F.; Lopes, M. C.; Mendes, A. F.To elucidate the role of endogenous inducible nitric oxide (NO) on the regulation of NF-jB activity in human chondrocytes, we evaluated (i) the pattern of expression of the neuronal (nNOS) and inducible (iNOS) NO synthase isoforms and the basal NF-jB activity in normal and osteoarthritic (OA) human chondrocytes, (ii) the role of cytokines and growth factors in modulating the protein levels of the two NOS isofor...
Delta sleep instability in children with chronic arthritis
Lopes,M.C.; Guilleminault,C.; Rosa,A.; Passarelli,C.; Roizenblatt,S.; Tufik,S.The objective of the present study was to evaluate the expression of a cyclic alternating pattern (CAP) in slow wave sleep (SWS) in children with the well-defined chronic syndrome juvenile idiopathic arthritis (JIA). Twelve patients (9-17 years of age), 7 girls, with JIA were compared to matched controls by age, pubertal stage and gender. After one night of habituation in the sleep laboratory, sleep measurement...
Universidade e Formação ao Longo da Vida
Alves, Mariana Gaio; Cabrito, B. G.; Lopes, M. C.; Martins, A. M.; Pires, A. L.
Development of a threshold positron spectrometer
Lopes, M. C. A.; Gordo, P. M.; Lima, A. P. de; Mohallem, J. R.We introduce a new positron spectroscopy experimental technique that we call threshold positron spectroscopy, by analogy with its similar threshold photoelectron spectroscopy. An apparatus that is being developed to explore this technique is described in this work. ; http://www.sciencedirect.com/science/article/B6TVT-4JW7WPW-3/1/a800a67732e0d75f39e5bc6014315e04
Effect of Skin Sensitizers on Inducible Nitric Oxide Synthase Expression and Ni...
Cruz, M. T.; Neves, B. M.; Gonçalo, M.; Figueiredo, A.; Duarte, C. B.; Lopes, M. C.Nitric oxide (NO) is involved in the pathogenesis of acute and chronic inflammatory conditions, namely in allergic contact dermatitis (ACD). However, the mechanism by which NO acts in ACD remains elusive. The present study focuses on the effects of different contact sensitizers (2,4-dinitrofluorbenzene, 1,4-phenylenediamine, nickel sulfate), the inactive analogue of DNFB, 2,4-dichloronitrobenzene, and two irrit...
Excitotoxicity mediated by Ca2+-permeable GluR4-containing AMPA receptors invol...
Santos, A. E.; Duarte, C. B.; Iizuka, M.; Barsoumian, E. L.; Ham, J.; Lopes, M. C.; Carvalho, A. P.; Carvalho, A. L.Cells preferentially expressing GluR4-containing alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors are particularly sensitive to excitotoxicity mediated through non-N-methyl-D-aspartate receptors. However, the excitotoxic signalling pathways associated with GluR4-containing AMPA receptors are not known. In this work, we investigated the downstream signals coupled to excitotoxicity media...
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