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Overactivation of calcineurin induced by amyloid-beta and prion proteins
Agostinho, Paula; Lopes, João P.; Velez, Zélia; Oliveira, Catarina R.Amyloid-beta protein (A[beta]) and the scrapie isoform of prion protein (PrPSs) have a central role in the pathogenesis of Alzheimer's disease (AD) and prion-related encephalopathies (PRE), respectively. In both disorders, the deposition of these misfolded proteins is accompanied by apoptotic neuronal loss. However, the pathogenesis and molecular basis of A[beta]- and PrPSc-neurotoxic effects are not completely...
Data: 2008
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Origem: Estudo Geral - Universidade de Coimbra
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