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The in vitro mechanical properties of small diameter Poly(vinyl) alcohol hydrog...
Alexandre, Nuno; Nunes, Natacha; Rodrigues, Miguel; Maurício, Ana Colette; Luís, Ana Lúcia; Lopes, Ascensão; Santos, José DomingosIntroduction The production of artificial vascular grafts of small diameter is a fluorescing line of investigation. PVA is a biomaterial that has been used for several biomedical applications and nowadays as a vascular graft. However the mechanical properties were never characterized in vitro. It was our objective to produce small diameter PVA grafts and characterize their physical and mechanical properties for...
In vivo evaluation of the potencial of mesenchymal stem cells (MSCs) from whart...
Alexandre, Nuno; Lopes, Ascensão; Rodrigues, Miguel; Amorim, Irina; Pereira, Tiaho; Gärtner, Andrea; Maurício, Ana Colette; Santos, José DomingosIntroduction: The use of cellular systems for improving biointegration of medical devices is a current trend of tissue engineering. The biocompatibility is a key aspect that can influence the performance of medical devices, for that reason inflammatory and foreign body reaction must be evaluated in pre-clinical studies. MSCs can modify the interaction of biomaterials with tissues by several mechanisms through t...
Application of Vascular grafts od Polyvinyl alcohol hydrogel associated to mese...
Alexandre, Nuno; Lopes, Ascensão; Nunes, Natacha; Amorim, Irina; Maurício, Ana Colette; Santos, José Domingos; Luís, Ana LúciaApplication of vascular grafts of the polyvinyl alcohol hydrogel (PVA) associated with MSCs from Wharton jelly in an animal model (sheep). N Alexandre, MA Lopes, N Fernandes, M Rodrigues, I Amorim, AC Mauricio, AL Luís Introduction: There is a great demand for new artificial vascular grafts of small diameter (< 6 mm) due to the functional limitations of the currently used biomaterials (ePTFE and Dacron). Polyv...
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