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Investigation and physicochemical characterization of vinpocetine-sulfobutyl et...
Ribeiro, Laura; Loftsson, Thorsteinn; Ferreira, Domingos; Veiga, FranciscoThe purpose of this study was to investigate the interactions between vinpocetine (VP), sulfobutyl ether beta-cyclodextrin (SBEbetaCD) and the water-soluble polymers polyvinylpyrrolidone (PVP) and hydroxypropyl methylcellulose (HPMC). The water-soluble polymers were shown to improve the complexation efficiency of SBEbetaCD, and thus less SBEbetaCD was needed to prepare solid VP-SBEbetaCD complexes in the presen...
Data: 2003
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Origem: Estudo Geral - Universidade de Coimbra
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