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The HIF1A Functional Genetic Polymorphism at Locus +1772 Associates with Progre...
Fraga, A; Ribeiro, R; Príncipe, P; Lobato, C; Pina, F; Maurício, J; Monteiro, C; Sousa, H; Calais da Silva, F; Lopes, C; Medeiros, RThe hypoxia inducible factor 1 alpha (HIF1a) is a key regulator of tumour cell response to hypoxia, orchestrating mechanisms known to be involved in cancer aggressiveness and metastatic behaviour. In this study we sought to evaluate the association of a functional genetic polymorphism in HIF1A with overall and metastatic prostate cancer (PCa) risk and with response to androgen deprivation therapy (ADT). The HIF...
The HIF1A Functional Genetic Polymorphism at Locus +1772 Associates with Progre...
Fraga, A; Ribeiro, R; Príncipe, P; Lobato, C; Pina, F; Maurício, J; Monteiro, C; Sousa, H; Calais da Silva, F; Lopes, C; Medeiros, RThe hypoxia inducible factor 1 alpha (HIF1a) is a key regulator of tumour cell response to hypoxia, orchestrating mechanisms known to be involved in cancer aggressiveness and metastatic behaviour. In this study we sought to evaluate the association of a functional genetic polymorphism in HIF1A with overall and metastatic prostate cancer (PCa) risk and with response to androgen deprivation therapy (ADT). The HIF...
Ogilvie's syndrome. Therapeutic efficacy of cecostomy.
Lobato, C; Unidade de Cuidados Intensivos, Hospital Garcia de Orta, Almada.; Póvoa, P; Murinello, F; Sabino, HOgilvie's syndrome is an uncommon clinical situation, which was first described in 1948. It is characterized by an acute colonic massive dilatation without evidence of organic obstruction. Association with extracolonic disease is a nearly constant feature. Clinically, the syndrome manifests itself as an acute abdominal distention the cecum being the site of greatest dilatation. This situation is rapidly progres...
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