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Signalling pathways in pollen germination and tube growth
Malhó, R.; Liu, Q.; Monteiro, D.; Rato, C.; Camacho, L.; Dinis, A.Summary. Signalling is an integral component in the establishment and maintenance of cellular identity. In plants, tip-growing cells represent an ideal system to investigate signal transduction mechanisms, and among these, pollen tubes (PTs) are one of the favourite models. Many signalling pathways have been identified during germination and tip growth, namely, Ca2+, calmodulin, phosphoinositides, protein kina...
Neurofilament proteins in neurodegenerative diseases
Liu, Q.; Xie, F.; Siedlak, S. L.; Nunomura, A.; Honda, K.; Moreira, P. I.; Zhua, X.; Smith, M. A.; Perry, G.The function of neurofilaments, the major component in large myelinated neurons, is not well understood even though they were discovered as structures over 100 years ago. Recent studies have suggested that neuro-filaments are closely related to many neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson disease Alzheimer disease, and diabetes. Using in vitro assays, cultures and transgenic...
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