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Desacyl-ghrelin does not influence insulin sensitivity
Veiga, Luísa; Brito, Miguel; Oliveira, Ana; Silva-Fortes, Carina; Silva-Nunes, JoséAcyl-ghrelin has been reported to increase food intake and adiposity and it is the best studied of the orexigenic gastrointestinal hormones. On the other hand, desacyl-ghrelin – DAG (the unacylated form of the hormone) has been reported as a potential player on carbohydrate metabolism. However, the potential impact of DAG on glucose homeostasis remains uncertain. In this study we aim to assess the association b...
Factors related with adiponectinemia in obese and normal-weight women and with ...
Silva-Nunes, José; Oliveira, Ana; Duarte, Leone; Barradas, Margarida; Melão, Alice; Brito, Miguel; Veiga, LuísaObjective: To assess different factors influencing adiponectinemia in obese and normal-weight women; to identify factors associated with the variation (Δ) in adiponectinemia in obese women following a 6-month weight loss program, according to surgical/non-surgical interventions. Methods: We studied 100 normal-weight women and 112 obese premenopausal women; none of them was on any medical treatment. Women were c...
Association of FTO and PPARG polymorphisms with obesity in Portuguese women
Carlos, Fábio Ferreira; Silva-Nunes, José; Flores, Orfeu; Brito, Miguel; Doria, Gonçalo; Veiga, Luísa; Baptista, Pedro VianaPurpose: We evaluated the association between risk of obesity in the Portuguese population and two obesity-related single-nucleotide gene polymorphisms: fat-mass and obesity-associated (FTO) rs9939609 and peroxisome proliferator-activated receptor gamma (PPARG) rs1801282. Patients and methods: A total of 194 Portuguese premenopausal female Caucasians aged between 18 and 50 years (95 with body mass index [BMI] ≥...
Q192R polymorphism of the paraoxonase-1 gene as a risk factor for obesity in Po...
Veiga, Luísa; Silva-Nunes, José; Melão, Alice; Oliveira, Ana; Duarte, Leone; Brito, MiguelIntroduction - Obesity became a major public health problem as a result of its increasing prevalence worldwide. Paraoxonase-1 (PON1) is an esterase able to protect membranes and lipoproteins from oxidative modifications. At the PON1 gene, several polymorphisms in the promoter and coding regions have been identified. The aims of this study were i) to assess PON1 L55M and Q192R polymorphisms as a risk factor for ...
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