Encontrados 5 documentos, a visualizar página 1 de 1
Early pseudoprogression following chemoradiotherapy in glioblastoma patients : ...
Reis, R. M.; Linhares, Paulo; Carvalho, Bruno; Figueiredo, Rita; Vaz, RuiEarly Pseudo-progression Following Chemoradiotherapy in Glioblastoma Patients: The Value of RANO Evaluation ; The aim of this study was to determine the frequency of pseudoprogression in a cohort of glioblastoma (GBM) patients following radiotherapy/temozolomide (RT/TMZ) by comparing Macdonald criterial to Response Assessment in Neuro-Oncology (RANO) criteria. The impact on prognosis and survival analysis was ...
Impact of EGFR genetic variants on glioma risk and patient outcome
Costa, Bruno Marques; Pereira, Marta Viana; Fernandes, Ricardo; Costa, S.; Linhares, Paulo; Vaz, Rui; Pinheiro, Céline; Lima, Jorge; Soares, PaulaB.M. Costa and M. Viana-Pereira contributed equally to this work; The authors thank the Immunochemotherapy Department of Hospital S. Marcos, and Clinica Laboratorial Dr. Edgar Botelho Moniz, S. Tirso, Portugal, for their helpful assistance in the management of controls ; BACKGROUND: The epidermal growth factor receptor (EGFR) regulates important cellular processes and is frequently implicated in human tumors. ...
Prognostic value of MGMT promoter methylation in glioblastoma patients treated ...
Costa, Bruno Marques; Caeiro, Cláudia; Guimarães, Inês; Martinho, Olga; Jaraquemada, Teresa; Augusto, Isabel; Castro, Lígia; Osório, LígiaGlioblastoma (GBM) is the most common and aggressive primary brain tumor. The identification of novel molecular prognostic markers of GBM has recently been an area of great interest in neuro-oncology. The methylation status of the MGMT gene promoter is currently a promising molecular prognostic marker, but some controversial data have precluded its clinical use. We analyzed MGMT methylation by methylation-speci...
Microsurgical approach of arteriovenous malformations in the central lobule
Chaddad-Neto,Feres; Joaquim,Andrei Fernandes; Santos,Marcos Juliano dos; Linhares,Paulo Wagner; Oliveira,Evandro deArteriovenous malformations (AVM) are neurovascular disorders that occur mainly in young adults. Their clinical presentation is variable and depends on its location, size and occurrence of bleeding. They can represent incidental findings in neuro radiological exams. The treatment of these lesions when located in eloquent areas, namely around the central sulcus, is controversial, with different therapeutical app...
Imaging in Parkinson disease surgery.
Basto, Margarida A; Linhares, Paulo; Sousa, Armando N; Rosas, M José; Garrett, Carolina; Mendes, Alexandre; Fonseca, Rosália; Amaral, Cristina; Vaz, RuiParkinson's disease is a progressive degenerative disease of the central nervous system frequently becoming motor disabling. Deep brain stimulation is one more therapeutic option. The authors describe the different steps of this therapeutic procedure with detail on imaging protocol to the precise and exact targeting of subthalamic nucleus. MR and CT imaging on stereotactic conditions are the imaging support to ...
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