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Investigation of the in vivo genotoxic effects of a titanium dioxide nanomateri...

Titanium dioxide nanomaterials (TiO2) are increasingly used in a diversity of products, including cosmetics, pharmaceuticals, food and inks, which contrasts with the existing uncertainties in respect to their risks for human and environment health. Previous studies on the genotoxicity of TiO2 reported discrepant findings, both in cellular and organismal systems. In a recent work, we showed that some nanosized T...

Importância da monitorização de cianobactérias em albufeiras portuguesas

Exploring a link between mycobacteria structure and virulence

Tuberculosis (TB) is a major health problem. The emergence of multidrug resistant (MDR)Mycobacterium tuberculosis (Mtb) isolates confounds treatment strategies. In Portugal, cases of MDR-TB are reported annually with increased incidence noted in Lisbon. The majority of these MDR-TB cases are due to closely-related mycobacteria known collectively as Lisboa family and Q1 cluster. The genetic determinants linked t...

Notas sobre a interdição de banhos em praias da área metropolitana de Lisboa

Morphologic characterization of Mycobacterium tuberculosis circulating strains ...

Abstrat publicado em: http://metallica.civil.ist.utl.pt/~patricia/SPMicros2012/book.pdf ; Tuberculosis (TB) is one of the major causes of mortality and morbidity worldwide accounting for 3.1 million deaths per year. This disease, caused by M. tuberculosis (Mtb) made a deadly, during the 1990’s, triggered mainly by the emergence of acquired immunodeficiency syndrome (AIDS). More recently, the emergence of multi...

Efeitos de microcistina-LR em células HepG2, Vero, MDCK e CaCo2

A microcistina-LR (MCLR) é amplamente reconhecida pela sua hepatotoxicidade. No entanto sabe-se que também afecta outros orgãos tais como o cérebro, rins e intestinos. Este trabalho tem como objectivo comparar os efeitos tóxicos da exposição a uma gama de concentrações de MCLR pura e de extractos de cianobactérias em linhas celulares hepáticas, renais e de intestino, representativas dos orgãos de acumulação da ...

Coleção de culturas de algas Estela Sousa e Silva

A coleção de culturas de algas Estela Sousa e Silva (ESSACC) foi criada em 1956 e reside atualmente no Laboratório de Biologia e Ecotoxicologia no Instituto Nacional de Saúde Dr. Ricardo Jorge. A ESSACC foi implementada em resposta à necessidade de um repositório de material biológico para investigação na área do fitoplâncton. Este importante recurso biológico contém culturas monoclonais de algas eucarióticas e...

Cytotoxic and morphological effects of microcystin-LR in in vitro models - a co...

Microcystin-LR (MCLR), a potent hepatotoxin, is transported selectively into the cells throught specific membrane polypeptides mostly present in the liver. These transporters are also expressed in the brain, kidneys and intestine, although the toxicity of MCLR in these cell types is still poorly understood. In this study, morphological, ultrastructural and biochemical analyses were performed in hepatic, renal a...

Estudo comparativo da citotoxicidade e alterações citopatológicas induzidas pel...

Microcystin-LR (MCLR) is a potent hepatotoxin produced by freshwater cyanobacteria, being responsible for acute and chronic hazards to animal and human health. Despite the increasing recognition of its toxic effects, the cellular basis of MCLR-induced toxicity is still poorly understood. In this work, morphological, ultrastructural and biochemical (MTT and Neutral Red-NR) analyses were performed to evaluate the...