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Lactoferrin and cancer disease prevention
Rodrigues, L. R.; Teixeira, J. A.; Schmitt, Fernando C.; Paulsson, Marie; Lindmark-Mässon, HelenaLactoferrin (LF) is an iron-binding glycoprotein that is composed of the transferrin family and is predominantly found in the products of the exocrine glands located in the gateways of the digestive, respiratory, and reproductive systems, suggesting a role in the non-specific defence against invading pathogens. Additionally, several physiological roles have been attributed to LF, namely regulation of iron homeo...
Significance of osteopontin expression in human invasive breast tumour stroma
Rodrigues, L. R.; Lopes, Nair; Sousa, Bárbara; Vieira, Daniella; Milanezi, Fernanda; Paulsson, Marie; Lindmark-Mässon, Helena; Teixeira, J. A.Osteopontin has been reported to stimulate cell adhesion, migration and specific signalling functions. Its overexpression has been found in melanoma, breast, lung, colorectal, stomach and ovarian cancer. However, its overexpression and role in human breast cancer remains to be elucidated. In this study, invasive breast tumours from 129 patients were examined by immunohistochemistry in order to assess osteoponti...
The role of osteopontin in tumour progression and metastasis in breast cancer
Rodrigues, L. R.; Teixeira, J. A.; Schmitt, Fernando C.; Paulsson, Marie; Lindmark-Mässon, HelenaThe use of cancer biomarkers to anticipate the outlines of disease has been an emerging issue, especially as cancer treatment has made such positive steps in the last few years. Progress in the development of consistent malignancy markers is imminent because advances in genomics and bioinformatics have allowed the examination of immense amounts of data. Osteopontin is a phosphorylated glycoprotein secreted by a...
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