Encontrados 54 documentos, a visualizar página 1 de 6
“Hipertensão intracraniana associada a hipervitaminose A”
Jacinto, Teresa Celeste; Hospital Divino Espírito Santo Ponta Delgada - HDES EPERA hipertensão intracraniana idiopática (HII) ou pseudotumor cerebri é uma entidade rara e habitualmente secundária na criança e adolescente. Clinicamente, o estrabismo (por atingimentos dos pares cranianos), a cefaleia e a rigidez da nuca são os sinais mais frequentes. As sequelas podem ser permanentes e graves como a perda da visão (parcial ou total). Relatamos o caso de um menino de 9 anos, com hipertensão in...
Common genetic polymorphisms in the ABCB1 gene are associated with risk of majo...
Santos, Marlene; Carvalho, Serafim; Lima, Luís; Nogueira, Augusto; Assis, Joana; Mota-Pereira, Jorge; Pimentel, Paulo; Maia, Dulce; Correia, DianaMajor depressive disorder (MDD) is a highly prevalent disorder, which has been associated with an abnormal response of the hypothalamus–pituitary–adrenal (HPA) axis. Reports have argued that an abnormal HPA axis response can be due to an altered P-Glycoprotein (P-GP) function. This argument suggests that genetic polymorphisms in ABCB1 may have an effect on the HPA axis activity; however, it is still not clear i...
FASL polymorphism is associated with response to bacillus Calmette-Guérin immun...
Lima, Luís; Ferreira, José Alexandre; Tavares, Ana; Oliveira, Daniela; Morais, António; Videira, Paula; Medeiros, Rui; Santos, LúcioObjective Deregulation of FAS/FASL system may lead to immune escape and influence bacillus Calmette-Guérin (BCG) immunotherapy outcome, which is currently the gold standard adjuvant treatment for high-risk non–muscle invasive bladder tumors. Among other events, functional promoter polymorphisms of FAS and FASL genes may alter their transcriptional activity. Therefore, we aim to evaluate the role of FAS and FASL...
Artificial Intelligence and Systems Theory Applied to Cooperative Robots: the S...
Pedro Lima; Luis CustódioThis paper describes an approach to the design of a population of cooperative robots based on concepts borrowed from Systems Theory and Artificial Intelligence The research has been developed under the SocRob project, jointly carried out by the Intelligent Control and Artificial Intelligence Laboratories at ISR/IST. The acronym of the project stands both for "Society of Robots" and "Soccer Robots", the case stu...
Navegação Entre Obstáculos Usando Um Método De Campos De Potencial Modificados
Bruno D. Damas; Pedro U. Lima; Luis M. CustódioThis paper describes a modified potential fields method for robot navigation, especially suited for unicycle-type non-holonomic mobile robots. The potential field is modified so as to enhance the relevance of obstacles in the direction of the robot motion. The angular speed and linear acceleration of the robot can then be expressed as functions of the linear speed, distance and relative orientation to the obsta...
Planeamento de Trajectórias usando Caminhos de Curvatura Contínua
Duarte C. Leão; Tiago C. Pereira; Pedro A. Lima; Luís M. M. CustódioThis paper proposes a method for real-time planning of continuous curvature paths in a structured environment. The building blocks of such paths are circle segments, straight-line segments and clothoids — the later being used to smoothly adapt the curvature profile of the resulting paths. The main application for this method would be to provide guidance for autonomous vehicles in a formula one like enviro...
Linfedema: revisão e integração de um caso clínico
Táboas, Maria Inês; Interna complementar de Medicina Física e de Reabilitação no Centro Hospitalar Tondela Viseu, PortugalO linfedema resulta da acumulação de líquido linfático no espaço intersticial do tecido subcutâneo e cursa habitualmente com uma evolução crónica e progressiva, condicionando morbilidade significativa e redução na qualidade de vida do indivíduo. O linfedema pode ser classificado de acordo com a etiopatogenia em Primário ou Secundário. O Linfedema Primário (LP) resulta de anomalias no desenvolvimento do sistema ...
Response of high-risk of recurrence/progression bladder tumours expressing sial...
Lima, Luís; Severino, Paulo; Silva, Mariana; Miranda, Andreia; Tavares, Ana; Pereira, Sofia; Fernandes, Elisabete; Cruz, Ricardo; Amaro, TeresinaHigh risk of recurrence/progression bladder tumours is treated with Bacillus Calmette-Guérin (BCG) immunotherapy after complete resection of the tumour. Approximately 75% of these tumours express the uncommon carbohydrate antigen sialyl-Tn (Tn), a surrogate biomarker of tumour aggressiveness. Such changes in the glycosylation of cell-surface proteins influence tumour microenvironment and immune responses that m...
The predominance of M2-polarized macrophages in the stroma of low-hypoxic bladd...
Lima, Luís; Oliveira, Daniela; Tavares, Ana; Amaro, Teresina; Cruz, Ricardo; Ferreira, José Alexandre; Santos, LúcioOBJECTIVE: Bacillus Calmette-Guérin (BCG) immunotherapy is the gold standard treatment for superficial bladder tumors with intermediate/high risk of recurrence or progression. However, approximately 30% of patients fail to respond to the treatment. Effective BCG therapy needs precise activation of the type 1 helper cells immune pathway. Tumor-associated macrophages (TAMs) often assume an immunoregulatory M2 phe...
Overexpression of tumour-associated carbohydrate antigen sialyl-Tn in advanced ...
Ferreira, José Alexandre; Videira, Paula; Lima, Luís; Pereira, Sofia; Silva, Mariana; Carrascal, Milene; Severino, Paulo; Fernandes, ElisabeteLittle is known on the expression of the tumour-associated carbohydrate antigen sialyl-Tn (STn), in bladder cancer. We report here that 75% of the high-grade bladder tumours, presenting elevated proliferation rates and high risk of recurrence/progression expressed STn. However, it was mainly found in non-proliferative areas of the tumour, namely in cells invading the basal and muscle layers. STn was also found ...
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