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Towards Targeted MRI: New MRI Contrast Agents for Sialic Acid Detection
Frullano, Luca; Rohovec, Jan; Aime, Silvio; Maschmeyer, Thomas; Prata, M. Isabel; Lima, J. J. Pedroso de; Geraldes, Carlos F. G. C.; Peters, Joop A.The detection of sialic acid in living systems is of importance for the diagnosis of several types of malignancy. We have designed and synthesized two new lanthanide ion ligands (L1 and L2) that are capable of molecular recognition of sialic acid residues. The basic structure of these ligands consists of a DTPA-bisamide (DTPA, diethylenetriamine pentaacetic acid) whose amide moieties each bear both a boronic fu...
Lanthanide(III) complexes of DOTA-glycoconjugates : a potential new class of le...
André, João P.; Geraldes, Carlos F. G. C.; Martins, J. A. R.; Merbach, André E.; Prata, M. I. M.; Santos, A. C.; Lima, J. J. Pedroso de; Tóth, ÉvaThe synthesis and characterization of a new class of DOTA (1,4,7,10-tetrakis(carboxymethyl)-1,4,7,10-tetraazacyclododecane) monoamide-linked glycoconjugates (glucose, lactose and galactose) of different valencies (mono, di and tetra) and their Sm(III), Eu(III) and Gd(III) complexes are reported. The proton NMR spectrum of Eu(III)-DOTALac(III) shows the predominance of a single structural isomer of square ...
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