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Mast, a conserved microtubule-associated protein required for bipolar mitotic s...
Lemos, Catarina L.; Sampaio, Paula; Maiato, Helder; Costa, Madalena; Omel’yanchuk, Leonid V.; Liberal, Vasco; Sunkel, Claudio E.Through mutational analysis in Drosophila, we have identified the gene multiple asters (mast), that encodes a new 165 kDa protein. mast mutant neuroblasts are highly polyploid and show severe mitotic abnormalities including the formation of mono- and multi-polar spindles organised by an irregular number of MTOCs of abnormal size and shape. The mast gene product is evolutionary conserved since homologues were id...
Data: 2000
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Origem: Repositório Aberto da Universidade do Porto
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