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The evolution of protein complexes by duplication of homomeric interactions
Pereira Leal, J.B.; Levy, E.D.; Kamp, C.; Teichmann, S.A.BACKGROUND: Cellular functions are accomplished by the concerted actions of functional modules. The mechanisms driving the emergence and evolution of these modules are still unclear. Here we investigate the evolutionary origins of protein complexes, modules in physical protein-protein interaction networks. RESULTS: We studied protein complexes in Saccharomyces cerevisiae, complexes of known three-dimensional st...
3D complex: a structural classification of protein complexes
Levy, E.D.; Pereira-Leal, J.B.; Chothia, C.; Teichmann, S.A.Most of the proteins in a cell assemble into complexes to carry out their function. It is therefore crucial to understand the physicochemical properties as well as the evolution of interactions between proteins. The Protein Data Bank represents an important source of information for such studies, because more than half of the structures are homo- or heteromeric protein complexes. Here we propose the first hiera...
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