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Lack of association of vitamin D receptor gene polymorphisms with susceptibilit...
Lemos, Manuel C.; Fagulha, Ana; Coutinho, Eduarda; Gomes, Leonor; Bastos, Margarida; Barros, Luisa; Carrilho, Francisco; Geraldes, ElizabeteThe vitamin D receptor (VDR) gene is a candidate gene for susceptibility to autoimmune disorders. Association studies of VDR polymorphisms and risk of type 1 diabetes often produced conflicting results in different ethnic backgrounds. The aim of this study was to test for association between common VDR polymorphisms and the genetic susceptibility to type 1 diabetes in the Portuguese population. We genotyped 207...
CYP2D6 genetic polymorphisms are associated with susceptibility to pituitary tu...
Gomes, Leonor; Lemos, Manuel C; Paiva, Isabel; Ribeiro, Cristina; Carvalheiro, Manuela; Regateiro, Fernando JSeveral polymorphisms of drug-metabolizing enzymes have been implicated in the susceptibility to tumor development. The role of the CYP2D6, GSTM1 and GSTT1 genes has been extensively studied, with alleles conferring different metabolic efficiencies and tumor risk. We studied the relationship between the main polymorphisms of these genes and the susceptibility to develop pituitary tumors, by performing a case-co...
Anaplastic thyroid tumor: retrospective analysis of 12 cases.
Martins, Teresa D; Carrilho, Francisco; Leitão, Patrícia; Lemos, Manuel C; Campos, Maria V; Geraldes, Elizabete; Carvalheiro, ManuelaAnaplastic thyroid tumor is a rare tumor and constitutes 5 to 10% of thyroid carcinomas. Is one of the most aggressive solid tumors and the prognosis is always fatal with a mean survival of 3 to 7 months. The current therapeutics are scarce and inefficacious. A retrospective analysis was performed in 12 clinical cases of anaplastic thyroid tumor observed at the Department of Endocrinology, Diabetes and Metaboli...
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