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MAST/Orbit has a role in microtubule-kinetochore attachment and is essential fo...
Maiato, Helder; Sampaio, Paula; Lemos, Catarina L.; Findlay, John; Mar, Carmena; Earnshaw, William C.; Sunkel, Claudio E.Multiple asters (MAST)/Orbit is a member of a new family of nonmotor microtubule-associated proteins that has been previously shown to be required for the organization of the mitotic spindle. Here we provide evidence that MAST/Orbit is required for functional kinetochore attachment, chromosome congression, and the maintenance of spindle bipolarity. In vivo analysis of Drosophila mast mutant embryos undergoing e...
Mast, a conserved microtubule-associated protein required for bipolar mitotic s...
Lemos, Catarina L.; Sampaio, Paula; Maiato, Helder; Costa, Madalena; Omel’yanchuk, Leonid V.; Liberal, Vasco; Sunkel, Claudio E.Through mutational analysis in Drosophila, we have identified the gene multiple asters (mast), that encodes a new 165 kDa protein. mast mutant neuroblasts are highly polyploid and show severe mitotic abnormalities including the formation of mono- and multi-polar spindles organised by an irregular number of MTOCs of abnormal size and shape. The mast gene product is evolutionary conserved since homologues were id...
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