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Níveis séricos de BDNF e S100B em um modelo animal de mania induzido por danfet...
Fries, Gabriel Rodrigo; Stertz, Laura; Valvassori, Samira da Silva; Andreazza, Ana Cristina; Leite, Marina Concli; Aguiar, Bianca Wollenhaupt de
Data: 2010
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Origem: OASIS br
Mixed lineage kinase 3 gene mutations in mismatch repair deficient gastrointest...
Velho, Sérgia; Oliveira, Carla; Paredes, Joana; Sousa, Sónia; Leite, Marina; Matos, Paulo; Milanezi, Fernanda; Ribeiro, Ana Sofia; Mendes, NunoMixed lineage kinase 3 (MLK3) is a serine/threonine kinase, regulating MAPkinase signalling, in which cancer-associated mutations have never been reported. In this study, 174 primary gastrointestinal cancers (48 hereditary and 126 sporadic forms) and 7 colorectal cancer cell lines were screened for MLK3 mutations. MLK3 mutations were significantly associated with MSI phenotype in primary tumours (P = 0.0005), o...
Data: 2010
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Origem: Repositório Científico do Instituto Nacional de Saúde
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