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Extended characterization of lipidic profile: evaluation of lipoprotein subfrac...

Dyslipidaemia is one major cause for atherosclerosis and cardiovascular disease. Atherogenicity of LDL particles vary with particle size, density and lipid composition. Smaller and denser subparticles are more atherogenic than the larger ones, so it’s important to quantify and know the type of sdLDL present in an individual in order to access cardiovascular risk. The aim of this study is to compare and evaluate...

O método de cascade screening na identificação de doentes com hipercolesterolem...

A Hipercolesterolemia Familiar (FH) é uma doença genética do metabolismo lipídico causada por mutações nos genes LDLR, APOB e PCSK9. Caracteriza-se clinicamente por níveis elevados de colesterol LDL, que se vão depositando nas artérias conduzindo ao desenvolvimento de doenças cardiovasculares prematuras. De acordo com a frequência europeia (1:500) estima-se que existam cerca de 20.000 indivíduos afectados com F...

Portuguese experience on cascade screening of index patients with FH

Portuguese experience on cascade screening of index patients with FH

Familial hypercholesterolaemia (FH) is an inherited disorder of cholesterol metabolism caused by mutations in LDLR, APOB and PCSK9 genes. FH has a estimated frequency of 1:500 in most European countries. Based on this frequency Portugal should have about 20000 cases of FH, however in our country this disorder is under-diagnosed.

The impact of cascade screening in familial hypercholesterolemia diagnosis

Familial hypercholesterolemia (FH) is a genetic disorder of cholesterol metabolism caused by mutations in LDLR, APOB and PCSK9 genes. It’s characterized by an increase of total and LDL cholesterol levels leading to premature cardiovascular disease. According to the frequency of the disease in most European countries (1:500 individuals) it is estimated that in Portugal exists about 20.000 cases of FH, but this ...

Cascade Screening in Familial Hypercholesterolemia importance in early detection

Ana Margarida Medeiros was funded by Portuguese Society of Cardiology; Ana Catarina Alves was funded by FCT SFRH / BD / 27990 / 2006; project grant FCT_PTDC/SAU-GMG/101874/2008; project grant FCT PIC/IC/83333/2007; project grant from Portuguese Society of Cardiology 2006-2009 and 2010-2012 Porto, November 2012 ; Familial hypercholesterolemia (FH) is a genetic condition mainly caused by mutations in LDLR but mi...

An analysis of the impacts of climatic variability and hydrology on the coastal...

The notion that climate change may impact coastal fish production suggests a need to understand how climatic variables may influence fish catches at different time scales. Evidence suggests that the effect of climatic variability and fishing effort on landed catches (as proxy of fish abundance) may vary at the regional scale. This study aims to assess the sensibility of two commercial species with a short life ...

Macrobenthic response to sewage discharges in confined areas from coastal lagoo...

We studied the effect of wastewater on macrobenthic assemblages and local Ecological Quality Status (EcoQS) along a pollution gradient. The study consisted of six sampling sites surrounding the discharge channel of a Wastewater Treatment Plant located within Ria Formosa coastal lagoon. The total number of individuals was significantly higher at the discharge point comparatively to the control site, while total ...

Algarve artificial reefs fish assemblages and trophic ecology: implications for...

Tese dout., Ciências e Tecnologias das Pescas, Universidade do Algarve, 2009

CA-125 AUC as a predictor for epithelial ovarian cancer relapse

PURPOSE: The aim of the present work was to evaluate the usefulness of CA-125 normalized in time area under the curve (CA-125 AUC) to signalise epithelial ovarian cancer relapse. PATIENTS AND METHODS: Data from a hundred and eleven patients were submitted to two different approaches based on CA-125 AUC increase values to predict patient relapse. In Criterion A total CA-125 AUC normalized in time value (AUC(i)) ...