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Influence of base material plastic behaviour and process parameters on friction...
Leitão, Carlos Miguel AlmeidaIn current work the weldability in friction stir welding (FSW) of two aluminium alloys currently used in welding construction, the Al-Mg-Si (AA6082-T6) and the Al-Mg (AA5083-H111) alloys, is analysed and related with base materials plastic properties at high temperatures and strain rates. The weldability of both alloys was evaluated by performing a deep morphological, microestrutural and mechanical characteriza...
Assessment of mechanical shear response using digital image correlation
Leitão, Carlos; Loureiro, Altino; Rodrigues, DulceIn this work, a special tool, developed for running shear tests using a universal tensile testing machine is described, as well as the procedures used for strain data acquisition via Digital Image Correlation (DIC). Testing procedures were developed and verified by testing two aluminium alloys widely used in welding construction, the heat-treatable AA6082-T6 and the non-heat-treatable AA5083-H111 aluminium allo...
Need of new clinical criteria for the identification of genetic Lynch syndrome.
Sousa, Rita; Lage, Pedro; Ferreira, Sara; Claro, Isabel; Francisco, Inês; Filipe, Bruno; Albuquerque, Cristina; Suspiro, Alexandra; Rodrigues, PaulaSurveillance programs in families with Hereditary Non-Polyposis Colorectal Cancer (HNPCC), which is an autossomal dominant disease, decrease colorectal carcinoma mortality. There are multiple clinical criteria for the identification of these families, mainly: the Amsterdam Criteria (ACI), the modified Amsterdam Criteria (ACII) and the Bethesda Guidelines (BG).To correlate, in families with HNPCC, the clinical c...
Risk of colorectal cancer associated with the C677T polymorphism in 5,10-methyl...
Guerreiro, Catarina Sousa; Carmona, Bruno; Gonçalves, Susana; Carolino, Elisabete; Fidalgo, Paulo; Brito, Miguel; Leitão, Carlos Nobre; Cravo, MaríliaBackground: Polymorphisms located in genes involved in the metabolism of folate and some methyl-related nutrients are implicated in colorectal cancer (CRC). Objective: We evaluated the association of 3 genetic polymorphisms [C677T MTHFR (methylene tetrahydrofolate reductase), A2756G MTR (methionine synthase), and C1420T SHMT (serine hydroxymethyltransferase)] with the intake of methyl-donor nutrients in CRC ris...
5' and 3' UTR thymidylate synthase polymorphisms modulate the risk of colorecta...
Carmona, Bruno; Guerreiro, Catarina Sousa; Cravo, Marília; Leitão, Carlos Nobre; Brito, MiguelThymidylate synthase, as a rate-limiting step in DNA synthesis, catalyses the conversion of dUMP into dTMP using 5,10-methylenotetrahydrofolate as the methyl donor. Two polymorphisms have been described in this gene: a repeat polymorphism in the 5' promoter enhancer region (3R versus 2R) and a 6 bp deletion in the 3' unstranslated region. Both of these may affect protein levels. The present case control study w...
The D1822V APC polymorphism interacts with fat, calcium, and fiber intakes in m...
Guerreiro, Catarina Sousa; Cravo, Marília; Brito, Miguel; Vidal, Pedro L.; Fidalgo, Paulo O.; Leitão, Carlos NobreBackground - Both genetic and environmental factors affect the risk of colorectal cancer (CRC). Objective - We aimed to examine the interaction between the D1822V polymorphism of the APC gene and dietary intake in persons with CRC. Design - Persons with CRC (n = 196) and 200 healthy volunteers, matched for age and sex in a case-control study, were evaluated with respect to nutritional status and lifestyle facto...
Importancia dos factores de aprendizagem na hipocondria
Serra, Adriano Supardo Vaz; Leitão, Carlos Martins; Ponciano, EmanuelOs autores estudaram 796 elementos da população em geral, 410 do sexo masculino e 386 do outro sexo, a fim de tentar conhecer quais das suas experiências prévias se ligavam à hipocondria. Verificaram existir uma dicotomia referente a preocupações com a doença ou a preocupações com a saúde, sendo só o primeiro caso que se relaciona com hipocondria. O hipocondríaco revela-se como um indivíduo de traços neuróticos...
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