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Carvedilol-mediated antioxidant protection against doxorubicin-induced cardiac ...
Oliveira, Paulo J.; Bjork, James A.; Santos, Maria S.; Leino, Richard L.; Froberg, M. Kent; Moreno, António J.; Wallace, Kendall B.The cardiotoxicity associated with doxorubicin (DOX) therapy limits the total cumulative dose and therapeutic success of active anticancer chemotherapy. Cardiac mitochondria are implicated as primary targets for DOX toxicity, which is believed to be mediated by the generation of highly reactive free radical species of oxygen from complex I of the mitochondrial electron transport chain. The objective of this stu...
Data: 2004
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Origem: Estudo Geral - Universidade de Coimbra
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