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Understanding the role of growth factors in modulating stem cell tenogenesis
Gonçalves, A. I.; Rodrigues, Márcia T.; Lee, S. J.; Atala, A.; Yoo, James; Reis, R. L.; Gomes, Manuela E.Current treatments for tendon injuries often fail to fully restore joint biomechanics leading to the recurrence of symptoms, and thus resulting in a significant health problem with a relevant social impact worldwide. Cell-based approaches involving the use of stem cells might enable tailoring a successful tendon regeneration outcome. As growth factors (GFs) powerfully regulate the cell biological response, thei...
Tenogenic potential of human stem cells from the amniotic fluid and adipose tissue
Rodrigues, Márcia T.; Gonçalves, Ana; Lee, S. J.; Atala, A.; Yoo, J. J.; Reis, R. L.; Gomes, Manuela E.Tendons are highly prone to injury and the intrinsic hypocellularity and hypovascularity make their natural healing extremely slow and inefficient when severed damaged. Surgical repair with grafts is common but unsuccessful in a long term basis. The development of tissue engineering strategies based on stem cells explores a natural endogenous system of regeneration with potential for tendon application. We prop...
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