We address a problem that often arises in industry, the multi-item capacitated-lot-sizing and scheduling problem with sequence-dependent setup times and costs. Powerful commercial solvers fail to solve even medium-sized instances of this NP-hard problem, therefore we employ a tabu search and a variable neighbourhood search meta-heuristic to solve it and compare the performance of these meta-heuristics over time...
Background—In the Occluded Artery Trial (OAT), 2201 stable patients with an occluded infarctrelated artery (IRA) were randomized to percutaneous coronary intervention (PCI) or optimal medical treatment alone (MED). There was no difference in the primary endpoint of death, re-MI or heart failure (CHF). We examined the prognostic impact of pre-randomization stress testing. Methods—Stress testing was required by p...
BACKGROUND: In the present study, we sought to determine whether opening a persistently occluded infarct-related artery (IRA) by percutaneous coronary intervention (PCI) in patients beyond the acute phase of myocardial infarction (MI) improves patency and indices of left ventricular (LV) size and function. METHODS AND RESULTS: Between May 2000 and July 2005, 381 patients with an occluded native IRA 3 to 28 day...
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