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Exercise attenuates levodopa-induced dyskinesia in 6-hydroxydopamine-lesioned mice

Jr., A. S. Aguiar; Moreira, E. L. G.; Hoeller, A. A.; Oliveira, P. A.; Córdova, F. M.; Glaser, V.; Walz, R.; Cunha, R. A.; Leal, R. B.; Latini, A.

l-DOPA alleviates the motor symptoms of Parkinson’s disease, but its long-term use is associated with undesirable dyskinesia. We now tested whether exercise can attenuate this l-DOPA-induced dyskinesia (LID). We tested the effects of exercise on LID in 6-hydroxydopamine hydrochloride-hemiparkinsonian mice. Animals were treated with l-DOPA/benserazide (25/12.5 mg/kg, i.p.) without and with possibility to exercis...


Influence of tool shoulder geometry on properties of friction stir welds in thi...

Galvão, I.; Leal, R. M.; Rodrigues, D. M.; Loureiro, A.

The aim of this work is to study the influence of the shoulder geometry on friction stir welding of 1 mm-thick copper-DHP plates. The welds were produced using three different shoulder geometries, flat, conical and scrolled, and varying the rotation and traverse speeds of the tool. The flat shoulder tool proved to be inadequate for performing welds, because many defects were produced for all welding conditions....


Estudo da Escala de Depressão, Ansiedade e Stresse para Crianças (EADS-C)

I. Leal; R. Antunes; T. Passos; José Luís Pais Ribeiro; J. Maroco


Mechanical behaviour of similar and dissimilar AA5182-H111 and AA6016-T4 thin f...

Leitão, C.; Leal, R. M.; Rodrigues, D. M.; Loureiro, A.; Vilaça, P.

The tensile behaviour of similar and dissimilar friction stir welds in 1 mm thick sheets of two aluminium alloys (AA5182-H111 and AA6016-T4) is analysed in this paper. The heterogeneity in properties across the welds was studied by performing microhardness tests and microstructural analysis. The tensile tests were performed in samples extracted longitudinal and transverse to the weld direction. It was found th...


Material flow in heterogeneous friction stir welding of thin aluminium sheets: ...

Leal, R. M.; Leitão, C.; Loureiro, A.; Rodrigues, D. M.; Vilaça, P.

http://www.sciencedirect.com/science/article/B6TXD-4T8HHG4-4/2/0b8e12809caaa618052d7b27494c16ac


Modeling and numerical study of actuator and sensor effects for a laminated pie...

Costa, L.; Figueiredo, I.; Leal, R.; Oliveira, P.; Stadler, G.

The aim of this paper is to derive a reduced model for a piezoelectric plate and to study its actuator and sensor capabilities. In the first part, we focus on the asymptotic modeling for thin plates formed by stacking layers of different piezoelectric materials. In the asymptotic model, the mechanical and electric unknowns are shown to be partly decoupled. In the second part, we study the actuator and sensor ca...


Smart capabilities of a laminated piezoelectric plate model

Costa, I.; Figueiredo, I.; Leal, R.; Oliveira, P.; Stadler, G.

This paper focuses on the modelling and analysis of actuator and sensor effects for thin laminated plates, which are formed by stacking several layers of different piezoelectric materials. We first discuss features and properties of a two-dimensional asymptotic model for a piezoelectric anisotropic plate, whose unknowns are the Kirchhoff-Love displacement and the electric potential. We prove that the latter is ...


Multiple- and single-objective approaches to laminate optimization with genetic...

Costa, L.; Fernandes, L.; Figueiredo, I.; Júdice, J.; Leal, R.; Oliveira, P.

In this paper an application of a genetic algorithm to a material- and sizing-optimization problem of a plate is described. This approach has obvious advantages: it does not require any derivative information and it does not impose any restriction, in terms of convexity, on the solution space. The plate optimization problem is firstly formulated as a constrained mixed-integer programming problem with a single o...


Influência da época de poda da planta matriz na produção de brotações para form...

MEDRADO, M.J.S.; COSTA, J.D.; FONSECA FILHO, H.; LEAL, R.S.; POMPERMEYR, S.A.

2000

Data: 2000   |   Origem: OASIS br

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    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia