l-DOPA alleviates the motor symptoms of Parkinson’s disease, but its long-term use is associated with undesirable dyskinesia. We now tested whether exercise can attenuate this l-DOPA-induced dyskinesia (LID). We tested the effects of exercise on LID in 6-hydroxydopamine hydrochloride-hemiparkinsonian mice. Animals were treated with l-DOPA/benserazide (25/12.5 mg/kg, i.p.) without and with possibility to exercis...
The aim of this work is to study the influence of the shoulder geometry on friction stir welding of 1 mm-thick copper-DHP plates. The welds were produced using three different shoulder geometries, flat, conical and scrolled, and varying the rotation and traverse speeds of the tool. The flat shoulder tool proved to be inadequate for performing welds, because many defects were produced for all welding conditions....
The tensile behaviour of similar and dissimilar friction stir welds in 1Â mm thick sheets of two aluminium alloys (AA5182-H111 and AA6016-T4) is analysed in this paper. The heterogeneity in properties across the welds was studied by performing microhardness tests and microstructural analysis. The tensile tests were performed in samples extracted longitudinal and transverse to the weld direction. It was found th...
http://www.sciencedirect.com/science/article/B6TXD-4T8HHG4-4/2/0b8e12809caaa618052d7b27494c16ac
The aim of this paper is to derive a reduced model for a piezoelectric plate and to study its actuator and sensor capabilities. In the first part, we focus on the asymptotic modeling for thin plates formed by stacking layers of different piezoelectric materials. In the asymptotic model, the mechanical and electric unknowns are shown to be partly decoupled. In the second part, we study the actuator and sensor ca...
This paper focuses on the modelling and analysis of actuator and sensor effects for thin laminated plates, which are formed by stacking several layers of different piezoelectric materials. We first discuss features and properties of a two-dimensional asymptotic model for a piezoelectric anisotropic plate, whose unknowns are the Kirchhoff-Love displacement and the electric potential. We prove that the latter is ...
In this paper an application of a genetic algorithm to a material- and sizing-optimization problem of a plate is described. This approach has obvious advantages: it does not require any derivative information and it does not impose any restriction, in terms of convexity, on the solution space. The plate optimization problem is firstly formulated as a constrained mixed-integer programming problem with a single o...
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