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Identification of protein sub-networks implicated in Autism Spectrum Disorders

Autism Spectrum Disorders (ASDs) represent a group of childhood neurodevelopmental disorders characterized by three primary areas of impairment: social interaction, communication, and restricted and repetitive patterns of interest or behavior. Although autism is one of the most heritable neuropsychiatric disorders, most of the known genetic risk has been traced to rare variants. Genome-wide association studies ...

Identification of protein subnetworks implicated in Autism Spectrum Disorders (...

Simulation of the velocity field in compound channel flow using different closu...

1st European IAHR Congress,6-4 May, Edinburg, Scotland ; In this study a comparison of three turbulence closure models (two isotropic and one anisotropic) with experimental data is performed. The interaction between the main channel (MC) flow and the floodplain (FP) generates a complex flow structure. A shallow mixing layer develops between the MC flow and the slower FP flow generating a high horizontal shear ...

Ultrasound velocity profile (UVP) measurements in shallow open-channel flows

1st European IAHR Congress, 6-4 May, Edinburgh, Scotland ; This paper is concerned with velocity measurements in shallow water flows by using Ultrasonic Velocity Profile (UVP)probes. The measurements were made in a 10 m long, 0.4 m wide flume whose slope is 0.00117. Diagonal and horizontal positioning of a single probe and the combination of two probes were tested as configurations of the UVP probes. Streamwis...

The thickness of the transport layer in stratified geomorphic flows

River Flow 2010 ; This paper is aimed at the development of a model for the thickness of the transport layer in stratified geomorphic flows such as sheet-flows or immature debris flows occurring, for instance, as a consequence of dam failure. These are flows with high geomorphic potential, occurring at or generating high shear stresses, whose ultimate driving mechanism is gravity. The micromechanical character...

Geomorphic dam-break flows. Part II: numerical simulation

Proceedings of the Institution of Civil Engineers - Water Management 163 Issue WM6

A conceptual model for sheet-flow drawn from rapid granular flow theories

33rd IAHR Congress: Water Engineering for a Sustainable Environment ; This paper is aimed at presenting i) a simple, yet sound, conceptual model applicable to the simulation of erosion, deposition and transport of cohesionless sediment in stratified flows under high shear stresses and ii) numerical solutions in idealized unsteady flow non-equilibrium transport situations. The conceptual model for the granular ...

Organised turbulence over mobile and immobile hydraulically rough boundaries

33rd IAHR Congress: Water Engineering for a Sustainable Environment ; The present work is aimed at the study of near-bed organised turbulence over mobile and immobile, porous, hydraulically rough boundaries. The bed was permeable and composed of non-cohesive sediments. Two data sets were analysed, characterised by the same u*. The mobile bed data featured generalised sediment transport for all size fractions s...

Maximum level and time to peak of dam-break waves on mobile horizontal bed

Journal of Hydraulic Engineering, Vol. 135, No. 11, November 1, 2009 ; This experimental study focuses the influence of bed material mobility and initial downstream water level on maximum water level and time to peak of dam-break waves. It covers horizontal bed conditions on fixed bed, sand bed, and pumice bed. Results include water surface level time evolution, maxima wave levels and time to peak. The influen...

The Ypt/Rab family and the evolution of trafficking in Fungi

The evolution of the eukaryotic endomembrane system and the transport pathways of their vesicular intermediates are poorly understood. A common set of organelles and pathways seems to be present in all free-living eukaryotes, but different branches of the tree of life have a variety of diverse, specialized organelles. Rab/Ypt proteins are small guanosine triphosphatases with tissue-specific and organelle-specif...