Encontrados 5 documentos, a visualizar página 1 de 1
Chitosan-based dressings loaded with neurotensin—an efficient strategy to impro...
Moura, Liane I. F.; Dias, Ana M. A.; Leal, Ermelindo C.; Carvalho, Lina; Sousa, Hermínio C. de; Carvalho, EugéniaOne important complication of diabetes mellitus is chronic, non-healing diabetic foot ulcers (DFUs). This study aims to develop and use dressings based on chitosan derivatives for the sustained delivery of neurotensin (NT), a neuropeptide that acts as an inflammatory modulator in wound healing. Three different derivatives, namely N-carboxymethyl chitosan, 5-methyl pyrrolidinone chitosan (MPC) and N-succinyl chi...
High glucose and oxidative/nitrosative stress conditions induce apoptosis in re...
Leal, Ermelindo C.; Aveleira, Célia A.; Castilho, Áurea F.; Serra, Andreia M.; Baptista, Filipa I.; Hosoya, Ken-Ichi; Forrester, John V.http://www.sciencedirect.com/science/article/B6WFD-4V94X19-2/2/49680e499c2d31bd74eb7ad7fc99a8c2
Inducible nitric oxide synthase isoform is a key mediator of leukostasis and bl...
Leal, Ermelindo C.; Manivannan, Ayyakkannu; Hosoya, Ken-Ichi; Terasaki, Tetsuya; Cunha-Vaz, José; Ambrósio, António Francisco; Forrester, John V.PURPOSE: Nitric oxide (NO) is involved in leukostasis and blood-retinal barrier (BRB) breakdown in the early stages of diabetic retinopathy (DR), but it is unclear which NO synthase (NOS) isoforms are primarily involved. In this study, the authors aimed to clarify the involvement of constitutive (eNOS, nNOS) and inducible NOS (iNOS) isoforms and the mechanisms underlying NO-mediated leukostasis and BRB breakdow...
Early calpain-mediated proteolysis following AMPA receptor activation compromis...
Araújo, Inês M.; Verdasca, Maria J.; Leal, Ermelindo C.; Bahr, Ben A.; Ambrósio, António F.; Carvalho, Arsélio P.; Carvalho, Caetana M.http://dx.doi.org/10.1111/j.1471-4159.2004.03043.x
Neurotoxicity Induced by Antiepileptic Drugs in Cultured Hippocampal Neurons: A...
Araújo, Inês M.; Ambrósio, António Francisco; Leal, Ermelindo C.; Verdasca, Maria João; Malva, João Oliveira; Soares-da-Silva, PatrícioPurpose: Newly designed antiepileptic drugs (AEDs) are being evaluated for their efficacy in preventing seizures and for their toxic profiles. We investigated and compared the toxic effects of two dibenz[b,f]azepine derivatives with anticonvulsant activity, 10,11-dihydro-10-hydroxyimino-5H-dibenz[b,f]azepine-5-carboxamide (BIA2-024) and (S)-(-)-10-acetoxy-10,11-dihydro-5H-dibenz[b,f] azepine-5-carboxamide (BIA2...
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