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Antitumor activity of hierridin B, a cyanobacterial secondary metabolite found ...

Cyanobacteria are widely recognized as a valuable source of bioactive metabolites. The majority of such compounds have been isolated from so-called complex cyanobacteria, such as filamentous or colonial forms, which usually display a larger number of biosynthetic gene clusters in their genomes, when compared to free-living unicellular forms. Nevertheless, picocyanobacteria are also known to have potential to pr...

Antitumor activity of hierridin B, a cyanobacterial secondary metabolite found ...

Cyanobacteria are widely recognized as a valuable source of bioactive metabolites. The majority of such compounds have been isolated from so-called complex cyanobacteria, such as filamentous or colonial forms, which usually display a larger number of biosynthetic gene clusters in their genomes, when compared to free-living unicellular forms. Nevertheless, picocyanobacteria are also known to have potential to pr...

What is in? pneumoperitoneum after sexual intercourse

The bed nucleus of stria terminalis and the amygdala as targets of antenatal gl...

Rationale: Several human and experimental studies have shown that early life adverse events can shape physical and mental health in adulthood. Stress or elevated levels of glucocorticoids (GCs) during critical periods of development seem to contribute for the appearance of neurospyschiatric conditions such as anxiety and depression, albeit the underlying mechanisms remain to be fully elucidated. Objectives: The...

Mechanisms of initiation and reversal of drug-seeking behavior induced by prena...

We would like to thank the members of the Neuroscience Research Domain at ICVS for all the helpful discussions and suggestions. We are especially thankful to the animal facility caretakers, and to Drs Sara Silva, António Melo and Ana Paula Silva and Dieter Fischer for their help ; Stress and exposure to glucocorticoids (GC) during early life render individuals vulnerable to brain disorders by inducing structur...

Giant recurrent retroperitoneal liposarcoma initially presenting as inguinal he...

Pedro Leão, Sónia Vilaça, Mário Oliveira and Joaquim Falcão have helped in the acquisition of data. Pedro Leão wrote the manuscript ; INTRODUCTION Liposarcomas comprise around 15% of soft tissue tumors. These tumors of mesodermal origin arise as single tumors, present one histologic type and diverse locations (including the retroperitoneum). Diagnosis of liposarcomas of retroperitoneum is difficult because o...

How to make discretionary fiscal policy countercyclical

In most countries, discretionary fiscal policy has often been pro-cyclical: instead of dampening the business cycle, actual discretionary policy has mostly magnified it. This paper proposes a mechanism that allows discretionary fiscal policy to be counter-cyclical. This involves the creation of a Budget Agency which carries out expenditures that, in addition to increasing its debt, also raise its saleable asset...

Consequências de desequilíbrios comerciais em câmbios fixos e em câmbios flexív...

No quadro do modelo ricardiano das vantagens comparativas, analisam-se as consequências de desequilíbrios nas balanças comerciais quando os países estão em câmbios flexíveis ou em câmbios fixos (com ou sem esterilização monetária). As principais conclusões são as seguintes: - Em câmbios flexíveis, os ajustamentos da taxa de câmbio conduzem às alterações nos custos relativos nec...

Comércio determinado por diferentes dotações de fatores produtivos entre países...

As apresentações habituais do modelo Hecksher-Ohlin (HO) nos livros de texto têm quatro problemas: análise por vezes superficial dos mecanismos económicos relevantes; escassa ilustração através de exemplos económicos concretos da capacidade explicativa do modelo; utilização de análises matemática e sobretudo gráfica frequentemente desnecessárias; e utilização da hipótese, muito discutível, de que a remuneração ...

Consequências de desequilíbrios comerciais em câmbios fixos e em câmbios flexív...

No quadro do modelo ricardiano das vantagens comparativas, analisam-se as consequências de desequilíbrios nas balanças comerciais quando os países estão em câmbios flexíveis ou em câmbios fixos (com ou sem esterilização monetária). As principais conclusões são as seguintes: - Em câmbios flexíveis, os ajustamentos da taxa de câmbio conduzem às alterações nos custos relativos necessárias para garantir a correcção...