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Microtubule-associated protein tau is essential for long-term depression in the...
Kimura, Tetsuya; Whitcomb, Daniel J.; Jo, Jihoon; Regan, Philip; Piers, Thomas; Heo, Seonghoo; Brown, Christopher; Hashikawa, Tsutomu; Murayama, MiyukiThe microtubule-associated protein tau is a principal component of neurofibrillary tangles, and has been identified as a key molecule in Alzheimer's disease and other tauopathies. However, it is unknown how a protein that is primarily located in axons is involved in a disease that is believed to have a synaptic origin. To investigate a possible synaptic function of tau, we studied synaptic plasticity in the hip...
Stress acts cumulatively to precipitate Alzheimer’s disease-like tau pathology ...
Sotiropoulos, I.; Catania, C.; Pinto, Lucilia G.; Silva, Rui; Pollerberg, G. Elizabeth; Takashima, Akihiko; Sousa, Nuno; Almeida, O. F. X.Stressful life experiences are likely tiological factors in sporadic forms of Alzheimer’s disease (AD). Many AD patients hypersecrete glucocorticoids (GCs), and their GC levels correlate with the rate of cognitive impairment and extent of neuronal atrophy. Severity of cognitive deficits in AD correlates strongly with levels of perphosphorylated forms of the cytoskeletal protein TAU, an essential mediator of the...
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