Encontrados 7 documentos, a visualizar página 1 de 1
A suggested classification for two groups of Campylobacter myoviruses
Javed, Muhammad Afzal; Ackermann, H. W.; Azeredo, Joana; Carvalho, Carla M.; Connerton, Ian; Evoy, Stephane; Hammerl, Jens Andre; Hertwig, StefanMost Campylobacter bacteriophages isolated to date have long contractile tails and belong to the family Myoviridae. Based on their morphology, genome size and endonuclease restriction profile, Campylobacter phages were originally divided into three groups. The recent genome sequencing of seven virulent campylophages reveal further details of the relationships between these phages at the genome organization leve...
Bacteriophage endolysins as a response to emerging foodborne pathogens
Oliveira, Hugo; Azeredo, Joana; Lavigne, Rob; Kluskens, LeonContinuous reports on foodborne outbreaks and increasing prevalence of antibiotic-resistant bacteria call for the development of novel preservation techniques that assure the safety of food products. Bacteriophage endolysins are highly active antibacterial peptidoglycan hydrolases that have evolved over millions of years to become the ultimate weapon against bacteria, with potential to be used as a food preserv...
Characterization of modular bacteriophage endolysins from Myoviridae phages OBP...
Walmagh, Maarten; Briers, Yves; Santos, Sílvio; Azeredo, Joana; Lavigne, RobPeptidoglycan lytic enzymes (endolysins) induce bacterial host cell lysis in the late phase of the lytic bacteriophage replication cycle. Endolysins OBPgp279 (from Pseudomonas fluorescens phage OBP), PVP-SE1gp146 (Salmonella enterica serovar Enteritidis phage PVP-SE1) and 201φ2-1gp229 (Pseudomonas chlororaphis phage 201φ2-1) all possess a modular structure with an N-terminal cell wall binding domain and a C-ter...
Characterization of modular bacteriophage endolysins from giant phiKZ related m...
Walmagh, Maarten; Briers, Briers; Santos, Sílvio; Azeredo, Joana; Lavigne, RobPeptidoglycan lytic enzymes (endolysins) of bacteriophages have a major role in bacterial lysis at the end of the phage replication cycle. These endolysins turned out to be potential antibacterial compounds to combat a broad range of Gram-positive pathogens, yet Gram-negative bacteria remain unharmed due to their impermeable outer membrane. With this background, we recently characterized three new endolysins fr...
The phage therapy paradigm : prêt-à-porter or sur-mesure?
Pirnay, Jean Paul; De Vos, Daniel; Verbeken, Gilbert; Merabishvili, Maia; Chanishvili, Nina; Vaneechoutte, Mario; Zizi, Martin; Laire, GeertThe present opinion is the result of discussions on the future of phage therapy (personalized or large-scale uniform therapy?) during the first International Congress on Viruses of Microbes, held at the Institut Pasteur in Paris on June 21–25, 2010.
Genomic and proteomic characterization of the broad host range Salmonella phage...
Santos, Sílvio; Kropinski, Andrew M.; Ceyssens, P. J.; Ackermann, H. W.; Villegas, A.; Carvalho, Carla M.; Lavigne, Rob; Krylov, V. N.; Ferreira, E. C.(Bacterio)phage PVP-SE1, isolated from a German wastewater plant, presents a high potential value as a biocontrol agent and as a diagnostic tool, even compared to the well-studied typing phage Felix 01, due to its broad lytic spectrum against different Salmonella strains. Sequence analysis of its genome (145,964 bp) shows it to be terminally redundant and circularly permuted. Its G C content, 45.6 mol%, is lowe...
Antibacterial activity on opportunistic Pseudomonas aeruginosa pathogen by a no...
Oliveira, Hugo; Walmagh, Maarten; Kluskens, Leon; Sillankorva, Sanna; Lavigne, Rob; Azeredo, JoanaThe Gram-negative pathogen Pseudomonas aeruginosa can cause severe infections of burn wound or cystic fibrosis on patients. Bacteriophage endolysin based strategy can offer a new alternative antimicrobial therapy. Endolysins are lytic enzymes that break down the peptidoglycan of bacterial cell wall at the late phage lytic cycle, however they are inactive on their own against Gram-negative bacteria when applied ...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||