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Diphenyl diselenide, a simple glutathione peroxidase mimetic, inhibits human LD...
Bem, Andreza Fabro de; Farina, Marcelo; Portella, Rafael de Lima; Nogueira, Cristina Wayne; Dinis, Teresa C. P.; Laranjinha, João A. N.Oxidative modification of low-density lipoprotein (LDL) represents an important factor in atherogenesis. In the present study, we have investigated the antioxidant capability of diphenyl diselenide (PhSe)2, a simple organoseleno compound, against copper (Cu2+) and peroxyl radical-induced human LDL oxidation in vitro. In initial studies using human serum, (PhSe)2 caused a dose-dependent inhibition of Cu2+-induce...
Inhibition of human LDL lipid peroxidation by phenol-rich beverages and their i...
Serafini, Mauro; Laranjinha, João A. N.; Almeida, Leonor M.; Maiani, G.Mounting evidence shows that phenol-rich beverages exert strong antioxidant activity. However, in vivo evidence has produced conflicting results. In the present study, we studied the impact of the ingestion of 300 mL of black and green tea, alcohol-free red wine, alcohol-free white wine, or water on plasma total antioxidant capacity in five healthy volunteers. Red wine has the highest content of phenolics (3.63...
Rapid isolation of low density lipoproteins in a concentrated fraction free fro...
Vieira, Otília V.; Laranjinha, João A.; Madeira, Vítor M.; Almeida, Leonor M.A rapid method is described for isolation and concentration of plasma low density lipoproteins (LDL) using a Beckman L80 ultracentrifuge equipped with a 70.1 Ti fixed angle rotor. The isolation of LDL achieved by a discontinuous gradient density step (180 min) was followed by a simultaneous purification and concentration step (45 min) using ultrafiltration through a collodium bag under nitrogen. This dialysis/c...
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