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Rac1 signalling modulates a STAT5/BCL-6 transcriptional switch on cell cycle-as...
Barros, Patrícia; Lam, Eric W-F; Jordan, Peter; Matos, PauloGene expression depends on binding of transcriptional regulators to gene promoters, a process controlled by signalling pathways. The transcriptional repressor B-cell lymphoma (BCL)-6 downregulates genes involved in cell-cycle progression and becomes inactivated following phosphorylation by the Rac1 GTPase-activated protein kinase PAK1. Interestingly, the DNA motifs recognized by BCL-6 and signal transducers and...
Data: 2012
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Origem: Repositório Científico do Instituto Nacional de Saúde
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