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A novel Rac1/PAK1/BCL-6/STAT5 pathway modulates the expression of cell-cycle-as...

Barros, Patrícia; Lam, Eric; Jordan, Peter; Matos, Paulo

Gene expression depends on binding of transcriptional regulators to gene promoters, a process controlled by signalling pathways. The transcriptional repressor BCL-6 downregulates genes involved in cell cycle progression and becomes inactivated following phosphorylation by the Rac1 GTPase activated protein kinase PAK1. Interestingly, the DNA motifs recognized by BCL-6 and STAT5 are similar. Because STAT5 stimula...


Rac1 signalling modulates a STAT5/BCL-6 transcriptional switch on cell cycle-as...

Barros, Patrícia; Lam, Eric W-F; Jordan, Peter; Matos, Paulo

Gene expression depends on binding of transcriptional regulators to gene promoters, a process controlled by signalling pathways. The transcriptional repressor B-cell lymphoma (BCL)-6 downregulates genes involved in cell-cycle progression and becomes inactivated following phosphorylation by the Rac1 GTPase-activated protein kinase PAK1. Interestingly, the DNA motifs recognized by BCL-6 and signal transducers and...


Rac1 signalling modulates a STAT5/BCL-6 transcriptional switch on cell-cycle-as...

Barros, Patricia; Lam, Eric; Jordan, Peter; Matos, Paulo

Gene expression depends on binding of transcriptional regulators to gene promoters, a process controlled by signalling pathways. The transcriptional repressor BCL-6downregulates genes involved in cell cycle progression and becomes inactivated following phosphorylation by the Rac1 GTPase activated protein kinase PAK1.Interestingly, the DNA motifs recognized by BCL-6 and STAT5 are similar. Because STAT5 stimulati...


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Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia