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Variations in salivary function in a rodent model of pre-diabetes
Rodrigues, Lénia; Mouta, Raquel; Barra, Cátia; Costa, Ana R; Silva, Fernando C; Lopes, Orlando; Lima, Mónica; Lamy, ElsaDiabetes is a widespread disease representing an enormous part of the total health costs. An early diagnostic could be of extremely importance both for the understanding and prevention of this pathology. Saliva is a fluid with increasing interest as a source of biomarkers for disease diagnostic and saliva protein composition changes have already been reported for diabetic individuals. However, the studies were ...
Avaliação das alterações na sensibilidade para os gostos doce e amargo em ratos...
Pinheiro, Sandra; Rodrigues, Lenia; Costa, Ana R; Antunes, Célia M; Silva, Fernando C; Lamy, ElsaA obesidade é actualmente considerada uma epidemia estando associada a uma predisposição genética do indivíduo e a um consumo energético desadequado O consumo de alimentos ricos em gordura é um dos factores que contribui para o ganho de peso e obesidade. O gosto é um factor determinante na escolha de alimentos e variações individuais na sensibilidade gustativa podem condicionar os hábitos alimentares. O present...
Glucose-evoked Na+,K+-ATPase modulation in pancreatic ß-cells from normal and i...
Roque, Cátia; Costa, Ana R; Antunes, Célia MNa+,K+-ATPase is regulated by glucose in pancreatic ß-cells, a process that is altered in glucose impaired tolerance. Although AMP dependent protein kinase (AMPK), a metabolic sensor, is believed to be central in the signal transduction cascade underlying the Na+,K+-ATPase regulation in pancreatic β-cells, its role remains unknown. The aim of this work was to clarify the role of AMPK in glucoseevoked inhibition...
Avaliação e Caraterização da Ação Inibitória de Iminociclitóis na Atividade α-G...
Louro, Patricia R; Vannuchi, Nicholas; Carreiro, Elisabete P; Costa, Ana R; Burke, Anthony J; Antunes, Célia MA diabetes, em particular a diabetes mellitus tipo 2, constitui um distúrbio metabólico que se carateriza por glicemias aumentadas resultantes de diminuição da libertação e/ou ação da insulina. Os inibidores das α-glucosidases surgem como agentes de elevado interesse terapêutico uma vez que podem contribuir para a diminuição da absorção intestinal de glicose e, consequentemente, para um desagravamento da hiperg...
Differences in salivary α-amylase levels among women with different taste sensi...
Sequeira, Márcia; Rodrigues, Lénia; Costa, Ana R; Pinheiro, C; Antunes, Célia M; Lamy, ElsaSaliva is the main component of taste receptor cells external environment, and consequently it may have a decisive role in taste perception. Taste sensitivity varies among different individuals. Sensitivity to the compound n-6-propylthiouracil (PROP) has been considerably studied and besides the known influence of genetic background, the contribution of perireceptor environment is not completely clear yet. Sali...
Protein Electrophoresis in Saliva Study
Lamy, Elsa; Costa, Ana R; Antunes, Celia M; Vitorino, Rui; Amado, FranciscoThe following sections will give an overview about the use of electrophoresis in saliva studies. Methodological issues and the major advantages and limitations for the use of this technique in human and animal saliva studies will be presented. We will finish the chapter by presenting alternatives to electrophoresis for the study of salivary proteome.
Isoenzymatic expression of Na, K-ATPase in Langerhans islets of glucose intoler...
Costa, Ana R; Capela e Silva, Fernando; Antunes, Célia M; Cruz Morais, Júlio MNa,K-ATPase is ubiquitously expressed in all eukaryotic cells where it acts as a regulator of Na+ and K+ homeostasis. The Na,K-ATPase pump consists of (αβ)22. The α-subunit contains the catalytic and ligand binding sites. The β-subunit is a glycosylated protein, and its role in Na,K-ATPase enzyme function remains somewhat obscure. Four α- and three β-isoforms have been described in mammals. The isoenzymatic exp...
A new approach for determination of Na,K-ATPase activity: application to intact...
Costa, Ana R.; Real, Joana; Antunes, Célia M.; Cruz-Morais, JúlioIt has been postulated that a decrease in Na,KATPase-mediated ion gradients may be a contributing mechanism to insulin secretion. However, the precise role of the Na,K-ATPase in pancreatic β-cell membrane depolarization and insulin secretion signalling have been difficult to evaluate, mostly because data reporting changes in enzymatic activity have been obtained in cell homogenates or membrane preparations, lac...
Efeito hipoglicemiante de um extracto aquoso de Cytisus multiflorus
Antunes, Celia M.; Areias, Laurinda R.; Vieira, Ines P.; Costa, Ana R.; Tinoco, M. Teresa; Cruz-Morais, J.Actualmente o interesse pelas plantas medicinais tem vindo a aumentar pois estas apresentam diversas actividades farmacológicas, entre as quais se inclui o efeito anti-diabético. A flora nativa portuguesa inclui várias plantas às quais se atribuem propriedades hipoglicemiantes, sem que estas tenham, no entanto, sido ainda cientificamente demonstradas. O objectivo deste trabalho foi estudar a possível acção hip...
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