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Allogeneic stem cell transplantation in patients with myelodysplastic syndrome:...
Rubio, S; Martins, C; Lacerda, J F; Carmo, J A; Lourenço, F; Lacerda, J M FWe determined the outcome of patients with myelodysplastic syndrome (MDS) and secondary acute myeloid leukemia (sAML) after allogeneic stem cell transplantation according to their international prognostic scoring system (IPSS) risk categories at diagnosis. A total of 11 females and 7 males, with a median age of 45 years, were transplanted. With a median follow-up of 60 months, the 6-year actuarial event-free su...
Autologous stem cell transplantation in acute myeloid leukemia. Factors influen...
Martins, Carlos; Lacerda, João F; Lourenço, Fernanda; Carmo, José A; Lacerda, J M FWe report our results of autologous stem cell transplantation (SCT) in patients with AML during the last 13 years. Between August 1990 and December 2003, 42 patients with acute myeloid leukemia (AML) received an autologous SCT. Patients were classified as standard risk if first complete remission (CR) was induced after one or two chemotherapy regimens and the white blood cell count at presentation was below 50,...
Bone marrow transplantation. Preliminary results.
Pimentel, P; Departamento de Hematologia, Hospital de Santa Maria, Lisboa.; de Lacerda, J MFrom May 1989 to March 1991 60 bone marrow transplants were performed--41 allogeneic and 19 autologous--in patients with malignant and nonmalignant hemopathies and solid tumors. The transplant related mortality was 19.4% and 10.5% for allografts and autografts, respectively. The projected relapse free survival at 22 months in patients with malignant hemopathies who underwent allotransplantation in early phase w...
Aplastic anemia. Alternative treatment by bone marrow transplantation.
Fonseca, T; Serviço Medicina I, Hospital de Santa maria, Lisboa.; Raposo, J; Gomez, B; d'Oliveira, J J; de Lacerda, J MWe report a case of a 25-year-old woman, with the diagnosis of severe aplastic anemia without a histocompatible sibling donor for bone marrow transplantation. The patient has been treated successfully with a combination of two immunosuppressive agents, cyclosporine and antilymphocyte globulin, after not responding to primary therapy with corticosteroids and growth factors. She showed a complete response to trea...
Methods for preserving bone marrow for autologous transplantation.
da Costa, F L; Unidade de Transplantação de Medula Ossea (UTMO) do Hospital de Santa Maria, Lisboa.; Pimentel, P; Tavares, A; Juncal, C; Lacerda, J MFor Autologous Bone Marrow Transplantation (ABMT) the patient's own marrow is harvested before myelotoxic high-dose radio-chemotherapy and later returned to promote hemopoietic reconstitution. Between harvest and return the bone marrow must be preserved. The time elapsed between harvest and return depends on the intended therapy. Although--bone marrow may keep its hematopoietic potential for a few days without ...
Treatment of acute promyelocytic leukemia with trans-retinoic acid. Experience ...
De Lacerda, J F; Unidade de Hematologia, Universidad de Lisboa, Hospital de Santa Maria, Faculdade de Medicina de Lisboa.; Do Carmo, J A; De Moura, M CAcute promyelocytic leukemia (APL) is a rare subtype of acute myelogenous leukemia that is usually associated with a fatal hemorrhagic diathesis. All trans-retinoic acid (ATRA) is an active metabolite of vitamin A that differentiates the malignant cell clone, corrects the coagulopathy, and induces complete remission in the vast majority of patients with APL. Between June 1992 and September 1993, 8 patients with...
Acute promyelocytic leukemia. The therapeutic advances.
de Lacerda, J F; Unidade de Hematologia, Hospital de Santa Maria, Faculdade de Medicina de Lisboa.; do Carmo, J A; de Lacerda, J MAcute promyelocytic leukemia (APL) is a rare subtype of acute myelogenous leukemia. It is frequently associated with a life-threatening hemorrhagic diathesis, often aggravated by induction cytotoxic chemotherapy. Patients with APL have bone marrow infiltration by abnormal promyelocytes, usually with prominent cytoplasmic granulation. These patients have a unique cytogenetic abnormality, a balanced reciprocal tr...
Psychiatric disorders in hospitalized patients with hematologic neoplasms.
dos Santos, M J; Núcleo de Psiquiatria de Ligação, Hospital Santa Maria, Lisboa.; Pimentel, P; Monteiro, J M; Cardoso, G; de Oliveira, J J; Almiro, MWe report the results of a year of regular psychiatric support in the Hematology Department (UTI-DH) at Santa Maria Hospital. During a six-month period, the total group of hospital inpatients suffering from leukemia, Hodgkin's disease or non-Hodgkin's lymphoma, were assessed, using a semi-structured interview. A prevalence of 30% of adjustment disorders (depression and/or anxiety) and 2% of organic mental syndr...
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