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Synthesis of some fenchyl-substituted alkenes and enol-ethers containing 3-oxyp...

Ciscato,Luiz Francisco M. L.; Bastos,Erick L.; Bartoloni,Fernando H.; Günther,Wolfgang; Weiss,Dieter; Beckert,Rainer; Baader,Wilhelm Josef

The synthesis of one fenchyl-substituted alkene and two enol-ethers, containing 3-oxyphenyl substituents by the Barton-Kellogg reaction is described. The tri-substituted aromatic fenchyl-alkene 1a was prepared in 53% yield from thiofenchone and a diazoanisole; whereas enol-ethers 1b and 1c were obtained (95 and 75% yield, respectively) using an inverse approach based on diazofenchone and aromatic thionoesters. ...

Data: 2010   |   Origem: OASIS br

Monitorização de praias e dunas usando fotografia aérea digital com georreferen...

J.A. Gonçalves; L. Bastos; H. Granja; J.P. Pinho; R. Henriques; A. Magalhães


The CTLA4 +49 A/G polymorphism is not associated with susceptibility to type 1 ...

Lemos, MC; Coutinho, E; Gomes, L; Bastos, M; Fagulha, A; Barros, L; Carrilho, F; Geraldes, E; Regateiro, FJ; Carvalheiro, M

CTLA4 genetic polymorphisms have been associated with type 1 diabetes. We genotyped 207 patients and 249 controls for the most frequently investigated polymorphism of the CTLA4 gene (+49A/G (rs231775)). No significant differences were observed, suggesting that this polymorphism is not strongly associated with type 1 diabetes in the Portuguese population.


An effective antidote for paraquat poisonings: the treatment with lysine acetyl...

R. J. Dinis Oliveira; H. Pontes; M. L. Bastos; F. Remião; J. A. Duarte; F. Carvalho


Lack of association of vitamin D receptor gene polymorphisms with susceptibilit...

Lemos, MC; Fagulha, A; Coutinho, E; Gomes, L; Bastos, M; Barros, L; Carrilho, F; Geraldes, E; Regateiro, FJ; Carvalheiro, M

The vitamin D receptor (VDR) gene is a candidate gene for susceptibility to autoimmune disorders. Association studies of VDR polymorphisms and risk of type 1 diabetes often produced conflicting results in different ethnic backgrounds. The aim of this study was to test for association between common VDR polymorphisms and the genetic susceptibility to type 1 diabetes in the Portuguese population. We genotyped 207...


Paraquat poisonings: mechanisms of lung toxicity, clinical features and treatment

R. J. Dinis Oliveira; J. A. Duarte; A. Sánchez-Navarro; F. Remião; M. L. Bastos; F. Carvalho


Sodium salicylate prevents paraquat-induced apoptosis in the rat lung

R. J. Dinis Oliveira; C. Sousa; F. Remião; J. A. Duarte; Rita Ferreira; A. Sánchez-Navarro; M. L. Bastos; F. Carvalho


PROP1 gene analysis in Portuguese patients with combined pituitary hormone defi...

Lemos, MC; Gomes, L; Bastos, M; Leite, V; Limbert, E; Carvalho, D; Bacelar, C; Monteiro, M; Fonseca, F; Agapito, A; Castro, JJ; Regateiro, FJ

OBJECTIVE: Mutations of the PROP1 gene lead to combined pituitary hormone deficiency (CPHD), which is characterized by a deficiency of GH, TSH, LH/FSH, PRL and, less frequently, ACTH. This study was undertaken to investigate the molecular defect in a cohort of patients with CPHD. DESIGN, PATIENTS AND MEASUREMENTS: A multicentric study involving 46 cases of CPHD (17 familial cases belonging to seven kindreds and...


Single high dose dexamethasone treatment decreases the pathological score and i...

R. J. Dinis Oliveira; J. A. Duarte; F. Remião; A. Sánchez-Navarro; M. L. Bastos; F. Carvalho


Paraquat exposure as an etiological factor of Parkinson's disease

R. J. Dinis Oliveira; F. Remião; H. Carmo; J. A. Duarte; A. Sánchez-Navarro; M. L. Bastos; F. Carvalho


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    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia