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Risk of multiple sclerosis after optic neuritis in patients with normal baselin...

Marques, IB; Matias, F; Silva, E; Cunha, L; Sousa, LD

When assessing and managing a patient with optic neuritis (ON), the risk of future development of multiple sclerosis (MS) is an important issue, as this can be the first presentation of the disease. Although the presence of lesions on baseline brain MRI is the strongest predictor of MS conversion, some patients with normal imaging also develop MS. We aimed to estimate MS risk in patients with ON and a normal ba...


Serum Zn Levels in Dysphagic Patients Who Underwent Endoscopic Gastrostomy for ...

Santos, C; Fonseca, J; Brito, J; Fernandes, T; Gonçalves, L; Sousa Guerreiro, A

Background and aims: Dysphagic patients who underwent endoscopic gastrostomy (PEG) usually present protein-energy malnutrition, but little is known about micronutrient malnutrition. The aim of the present study was the evaluation of serum zinc in patients who underwent endoscopic gastrostomy and its relationship with serum proteins, whole blood zinc, and the nature of underlying disorder. Methods: From patients...


WORKSHOP NACIONAL “INVESTIGAÇÃO EM OLIVICULTURA E AZEITE - RESULTADOS E APLICAÇÕES

Santos, Francisco L.; Sousa, Adélia O.; Rei, Fernando; Garcia, Raquel; Coelho, Renato R.; Perdigão, Joana

Workshop Nacional “Investigação em Olivicultura e Azeite – Resultados e Aplicações” De 27-06-2013, 09:00 a 28-06-2013 Sala de Conferências do Pólo da Mitra da Universidade de Évora O Workshop Nacional dedicado ao tema “Investigação em Olivicultura e Azeite – Resultados e Aplicações” realizou-se nos dias 27 e 28 de junho de 2013. Pretendeu-se com este evento, dirigido a produtores, técnicos, e todos os interes...


Excitotoxic lesions in the central nucleus of the amygdala attenuate stress-ind...

Silva, Ana Paula Ventura; Melo, António; Ferreira, Ana Catarina; Carvalho, M. M.; Campos, Filipa L.; Sousa, Nuno; Pêgo, José M.

The extended amygdala, composed by the amygdaloid nuclei and the bed nucleus of the stria terminalis (BNST), plays a critical role in anxiety behavior. In particular, the link between the central nucleus of the amygdala (CeA) and the BNST seems to be critical to the formation of anxiety-like behavior. Chronic unpredictable stress (CUS) exposure is recognized as a validated animal model of anxiety and is known t...


Carotid artery bifurcation modelling from patient CT angiography and ultrasound...

A. Santos; J. Tavares; L. Sousa; C. Castro; C. António; R. Santos; P. Castro; E. Azevedo


Computer simulation of the cardiovascular system

A. Santos; L. Sousa; J. Tavares; R. Santos; P. Castro; E. Azevedo


POTENCIAL DE VÁRIAS TECNOLOGIAS PARA MELHORAR A EFICIÊNCIA ENERGÉTICA NA AGRICU...

Baptista, F.J.; Silva, L.L.; Sousa, A.; Silva, J.R.

Este trabalho versa sobre o potencial de várias tecnologias para melhorar a eficiência energética na agricultura e consiste num resumo da apresentação feita em Quito, Equador no Primeiro Fórum Ibero-Americano de Ciências para as Energias, em Junho de 2012. Os dados estatísticos nos vários países, relativos ao consumo de energia pelo sector agro-pecuário não reflectem na maior parte dos casos a realidade, pecand...


Individual common variants exert weak effects on the risk for autism spectrum d...

Anney, R.; Klei, L.; Pinto, D.; Almeida, J.; Bacchelli, E.; Baird, G.; Bolshakova, N.; Bölte, S.; Bolton, P.F.; Bourgeron, T.; Brennan, S.; Brian, J.

While it is apparent that rare variation can play an important role in the genetic architecture of autism spectrum disorders (ASDs), the contribution of common variation to the risk of developing ASD is less clear. To produce a more comprehensive picture, we report Stage 2 of the Autism Genome Project genome-wide association study, adding 1301 ASD families and bringing the total to 2705 families analysed (Stage...


Suitability of silk-based 3D biotextiles seeded with human adipose-derived stem...

Ribeiro, V. P.; Martins, A. R.; Marques, A. P.; Bonifácio, G.; Oliveira, A. L.; Sousa, R. A.; Reis, R. L.

Human Adipose-derived Stem Cells (hASCs) became an emerging possibility for tissue replacement therapies, such as bone tissue regeneration. Due to their osteogenic differentiation potential, easy isolation, expansion and in vitro proliferation, they have become a highly potential source of seed cells to be seeded in bone tissue engineering (TE) constructs and have demonstrated promising prospects in bone regene...


Hyaluronic acid/poly(amidoamine) dendrimer nanoparticles for central nervous sy...

Silva, Barbara L.; Cerqueira, Susana R.; Fevereiro, J. P.; Pirraco, R. P.; Marques, A. P.; Oliveira, Joaquim M.; Reis, R. L.; Sousa, Nuno

Central nervous system (CNS) disorders are among the diseases with less efficiency in treatment. In order to reach its target and exert its effect within the brain parenchyma, drugs must overcome the blood brain barrier (BBB) and the blood-cerebrospinal fluid-brain (BCSFB). The aim of this work was to develop a novel nano-based dendrimer which could serve as a nanocarrier with the ability to cross these barri- ...


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    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia