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Amide conjugates of the DO3A-N-(alfa-amino)propionate ligand : leads for stable...
Ferreira, Miguel Filipe Moreira Marques; Martins, André F.; Martins, Catarina I. O.; Ferreira, Paula M. T.; Tóth, Éva; Rodrigues, Tiago B.A novel synthetic methodology for preparing amide conjugates of the DO3A-N-(alfa-amino)propionate chelator is described, using the synthesis of the DO3A-N-(alfa-benzoylamido)propionate chelator as an illustrative example. The model Gd(DO3A-N-(alfa-benzoylamido)propionate) chelate displays accelerated water exchange, stability in a wide pH range and inertness towards transmetallation by Zn2+. The Gd(DO3A-N-(al...
Gd(III)-EPTPAC16, a new self-assembling potential liver MRI contrast agent: in ...
Torres, Suzana; Prata, Maria I. M.; Santos, Ana C.; André, João P.; Martins, José A.; Helm, Lothar; Tóth, Éva; García-Martín, Maria L.The recently reported amphiphilic chelate, [Gd(EPTPAC16)(H2O)]2-, forms supramolecular aggregates in aqueous solution by self-assembly of the monomers with a relaxometrically determined critical micellar concentration (CMC) of 0.34 mM. The effect of sonication on the aggregate size was characterized by dynamic light scattering and relaxometry, indicating the presence of premicellar aggregates and an overall dec...
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