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Interleukin-17 as a Therapeutic Target in Psoriasis
Psoriasis is a chronic, immune-mediated inflammatory disease that affects up to 1-3% of the general population. An advanced understanding of the immune-pathogenesis of psoriasis has led to the development of new drugs that refine existing treatments or target novel molecular and immunologic pathways. IL-17 and Th17 cells play an important role in the pathogenesis of several autoimmune and immune-mediated disord...
STRUMA OVARII COEXISTING WITH DERMATOMYOSITIS - AN UNUSUAL ASSOCIATION
Dermatomyositis is an idiopathic inflammatory myopathy with cutaneous involvement. In patients over 60 years may be associated with underlying neoplasms. The most frequently involved are the lung, ovary and digestive system. The Struma ovarii is a rare ovarian tumor, which is defined by the presence of thyroid tissue, associated to a teratoma or a mucinous cystadenoma. There are benign and malignant histologica...
Diagnóstico de Sífilis a Partir de Lesões da Mucosa Oral
Uva, Luis; Clínica Universitária de Dermatologia. Hospital de Santa Maria. Lisboa. Portugal.Palavras-chave: Doenças da Boca; Sífilis; Sífilis Cutânea; Treponema pallidum. ; Keywords: Mouth Diseases; Syphilis; Syphilis, Cutaneous; Treponema pallidum.
Distribution and quantitation of skin iron in primary haemochromatosis: correla...
Pinheiro, Teresa; Silva, Raquel; Fleming, Rita; Gonçalves, Afonso; Barreiros, Maria Alexandra; Silva, João N.; Morlière, Patrice; Santus, RenéMeasurement of the concentration of iron in the skin, if correlated with total body iron stores, may enable better informed decisions on when to initiate, change or stop therapy in hereditary heamochromatosis. Naïve haemochromatosis patients with iron overload and with C282Y and/or H63D HFE mutations were evaluated at the following time-points: disease diagnosis, end of the therapy programme, and 6 months afte...
Onicogrifose
Uva, Luis; Clínica Universitária de Dermatologia. Hospital de Santa Maria. Centro Hospitalar Lisboa Norte. Lisboa. Portugal.Palavras-chave: Unhas Malformadas. ; Keywords: Nails, Malformed.
PYODERMA GANGRENOSUM ASSOCIATED WITH HIDRADENITIS SUPURATIVA – A RARE BUT WELL ...
Pyoderma gangrenosum (PG) and hidradenitis suppurativa (HS) are inflammatory diseases of unknown aetiology, which association is rare but well established. We describe the case of a 27-year-old female patient, with axillary and inguinal hidradenitis supurativa lesions since four years ago who developed a pyoderma gangrenosum lesion in her right leg. Treatment was instituted with systemic corticosteroids in inpa...
IL-17 – A NEW THERAPEUTIC TARGET IN PSORIASIS
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PROZONE PHENOMENON IN SECONDARY SYPHILIS. THE IMPORTANCE OF COMMUNICATION BETWE...
Vasconcelos, Pedro; Interno de Dermatologia e Venereologia/Resident, Dermatology and VenereologyThe prozone phenomenon is defined as a falsely negative test due to very high titters of antibody, as high titters of antigen or antibody may prevent the formation of antigen-antibody complexes in laboratory tests of many diseases, like syphilis or brucellosis. We describe the case of a 27 year old caucasian male admitted in the emergency room with enlarged palpable lymph nodes and a skin eruption either sugges...
TRIANGULAR SKIN GRAFT OF THE NOSE BY ANATOMICAL CONTIGUITY
Pacheco, David; Clínica Universitária Dermatológica do Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, PortugalReconstruction of large nasal defects, represents a challenge for Dermatologic Surgeon. We present a 87-year-old patient, with a large dimension squamous cell carcinoma, 3x2cm in the dorsum and the root of the nose. The surgical defect had a triangular shape. The realization of a flap conditioned a great movement of tissue and time- -consuming surgery. Due to the patient co-morbidities, was performed a total sk...
GENITAL ULCERS IN FEMALE ADOLESCENTS - DIFFERENTIAL DIAGNOSIS
Introduction: Genital aphtosis is the most frequent cause of non-infectious vulvar ulceration, usually associated to oral aphtosis and it is always an exclusion diagnosis. We present three cases of genital ulcer in female adolescents, observed in our Dermatology clinic. Case 1: A 17-year-old-girl, with past history of oral aphtosis, was referred to our clinic with a genital ulcer, fever, asthenia and myalgia. ...
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