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Cardioselective and cumulative oxidation of mitochondrial DNA following subchro...
Serrano, J.; Palmeira, C. M.; Kuehl, D. W.; Wallace, K. B.We recently reported the preferential accumulation of 8-hydroxydeoxyguanosine (8OHdG) adducts in cardiac mitochondrial DNA (mtDNA) following acute intoxication of rats with doxorubicin (C.M. Palmeira et al., Biochim. Biophys. Acta, 1321 (1997) 101-106). The concentration of 8OHdG adducts decreased to control values within 2 weeks. Since conventional antineoplastic therapy entails repeated administration of smal...
Data: 1999
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Origem: Estudo Geral - Universidade de Coimbra
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