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Genomic and proteomic characterization of the broad host range Salmonella phage...
Santos, Sílvio; Kropinski, Andrew M.; Ceyssens, P. J.; Ackermann, H. W.; Villegas, A.; Carvalho, Carla M.; Lavigne, Rob; Krylov, V. N.; Ferreira, E. C.(Bacterio)phage PVP-SE1, isolated from a German wastewater plant, presents a high potential value as a biocontrol agent and as a diagnostic tool, even compared to the well-studied typing phage Felix 01, due to its broad lytic spectrum against different Salmonella strains. Sequence analysis of its genome (145,964 bp) shows it to be terminally redundant and circularly permuted. Its G C content, 45.6 mol%, is lowe...
Salmonella Enteritidis bacteriophage candidates for phage therapy of poultry
Sillankorva, Sanna; Pleteneva, E. A.; Shaburova, O. V.; Santos, Sílvio; Carvalho, Carla A. O. C. M.; Azeredo, Joana; Krylov, V. N.Aims: Salmonella is a worldwide foodborne pathogen causing acute enteric infections in humans. In the recent years, the use of bacteriophages has been suggested as a possible tool to combat this zoonotic pathogen in poultry farms. This work aims to isolate and perform comparative studies of a group of phages active against a collection of specific Salmonella Enteritidis strains from Portugal and England. Also...
Selection and characterization of a multivalent Salmonella phage and its produc...
Santos, Sílvio; Fernandes, E.; Carvalho, Carla M.; Sillankorva, Sanna; Krylov, V. N.; Pleteneva, E. A.; Shaburova, O. V.; Nicolau, Ana; Ferreira, E. C.We report the selection and amplification of the broad-host-range Salmonella phage phi PVP-SE1 in an alternative nonpathogenic host. The lytic spectrum and the phage DNA restriction profile were not modified upon replication in Escherichia coli Bl21, suggesting the possibility of producing this phage in a nonpathogenic host, contributing to the safety and easier approval of a product based on this Salmonella bi...
Safety issues concerning phage therapy for veterinary applications
Azeredo, Joana; Ferreira, E. C.; Gannon, B. W.; Carvalho, Carla A. O. C. M.; Santos, Sílvio; Krylov, V. N.Phages have been proposed as natural antimicrobial agents to fight bacterial infections in animals. This is supported by several scientific evidences of the efficacy of phage therapy for veterinary applications. However, there are important safety issues that should be taken into consideration when developing a phage product for veterinary applications. For example it is of utmost importance to guarantee that p...
Production of a salmonella bacteriophage in a non-pathogenic E. coli strain
Santos, Sílvio; Fernandes, E.; Krylov, V. N.; Pleteneva, E. A.; Shaburova, O. V.; Nicolau, Ana; Ferreira, E. C.; Azeredo, Joana
Bacteriophage therapy in salmonella infected broiler chickens
Gannon, B. W.; Halfhide, D. E.; Zammerini, D.; Hayes, C. M.; Krylov, V. N.; Nicolau, Ana; Azeredo, Joana; Roe, J. M.
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