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An AIF orthologue regulates apoptosis in yeast
Wissing, Silke; Ludovico, Paula; Herker, Eva; Buttner, Sabrina; Engelhardt, Silvia; Decker, Thorsten; Link, Alexander; Proksch, AstridApoptosis-inducing factor (AIF), a key regulator of cell death, is essential for normal mammalian development and participates in pathological apoptosis. The proapoptotic nature of AIF and its mode of action are controversial. Here, we show that the yeast AIF homologue Ynr074cp controls yeast apoptosis. Similar to mammalian AIF, Ynr074cp is located in mitochondria and translocates to the nucleus of yeast cells ...
Coevolution of hosts and microorganisms: an analysis of the involvment of cytok...
Williams,Owen; Gonzalo,José Angel; Martínez-A.,Carlos; Kroemer,GuidoParasites may employ particular strategies of eluding an immune response by taking advantage of those mechanisms that normally guarantee immunological self-tolerance. Much in the way as it occurs during the establishment of self-tolerance, live pathogens may induce clonal deletion, functional inactivation(anergy) and immunosupression. At this latter level, it appears that certain pathogens produce immunosupresi...
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